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Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens

Authors
 Hayoung Song  ;  Haein Shin  ;  Hunkyu Seo  ;  Wonjung Park  ;  Byung Jun Joo  ;  Jeongho Kim  ;  Jeonghyun Kim  ;  Hong Kyun Kim  ;  Jayoung Kim  ;  Jang-Ung Park 
Citation
 ADVANCED SCIENCE, Vol.9(28) : e2203597, 2022-10 
Journal Title
ADVANCED SCIENCE
ISSN
 * 
Issue Date
2022-10
MeSH
Animals ; Biosensing Techniques* ; Cholesterol ; Contact Lenses, Hydrophilic* ; Humans ; Rabbits ; Reproducibility of Results ; Tears
Keywords
cholesterol ; healthcare device ; smart contact lens ; stretchable antenna ; wireless communication
Abstract
Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.
Files in This Item:
T202204328.pdf Download
DOI
10.1002/advs.202203597
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jayoung(김자영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192154
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