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Cited 11 times in

Clinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysis

DC Field Value Language
dc.contributor.author신재일-
dc.contributor.author이성수-
dc.contributor.author김아영-
dc.contributor.author우원기-
dc.date.accessioned2022-12-22T04:10:36Z-
dc.date.available2022-12-22T04:10:36Z-
dc.date.issued2022-09-
dc.identifier.issn0146-6615-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192065-
dc.description.abstractTo provide a comparative meta-analysis and systematic review of the risk and clinical outcomes of coronavirus 2019 (COVID-19) infection between fully vaccinated and unvaccinated groups. Eighteen studies of COVID-19 infections in fully vaccinated ("breakthrough infections") and unvaccinated individuals were reviewed from Medline/PubMed, Scopus, Embase, and Web of Science databases. The meta-analysis examined the summary effects and between-study heterogeneity regarding differences in the risk of infection, hospitalization, treatments, and mortality between vaccinated and unvaccinated individuals. he overall risk of infection was lower for the fully vaccinated compared to that of the unvaccinated (relative risk [RR] 0.20, 95% confidence interval [CI]: 0.19-0.21), especially for variants other than Delta (Delta: RR 0.29, 95% CI: 0.13-0.65; other variants: RR 0.06, 95% CI: 0.04-0.08). The risk of asymptomatic infection was not statistically significantly different between fully vaccinated and unvaccinated (RR 0.56, 95% CI: 0.27-1.19). There were neither statistically significant differences in risk of hospitalization (RR 1.06, 95% CI: 0.38-2.93), invasive mechanical ventilation (RR 1.65, 95% CI: 0.90-3.06), or mortality (RR 1.19, 95% CI: 0.79-1.78). Conversely, the risk of supplemental oxygen during hospitalization was significantly higher for the unvaccinated (RR 1.40, 95% CI: 1.08-1.82). Unvaccinated people were more vulnerable to COVID-19 infection than fully vaccinated for all variants. Once infected, there were no statistically significant differences in the risk of hospitalization, invasive mechanical ventilation, or mortality. Still, unvaccinated showed an increased need for oxygen supplementation. Further prospective analysis, including patients' risk factors, COVID-19 variants, and the utilized treatment strategies, would be warranted.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJOURNAL OF MEDICAL VIROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCOVID-19 Vaccines-
dc.subject.MESHCOVID-19*-
dc.subject.MESHCoronavirus Infections*-
dc.subject.MESHHumans-
dc.subject.MESHSARS-CoV-2-
dc.titleClinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorChristine J Lee-
dc.contributor.googleauthorWongi Woo-
dc.contributor.googleauthorAh Young Kim-
dc.contributor.googleauthorDong Keon Yon-
dc.contributor.googleauthorSeung Won Lee-
dc.contributor.googleauthorAi Koyanagi-
dc.contributor.googleauthorMin Seo Kim-
dc.contributor.googleauthorKalthoum Tizaoui-
dc.contributor.googleauthorElena Dragioti-
dc.contributor.googleauthorJoaquim Radua-
dc.contributor.googleauthorSungsoo Lee-
dc.contributor.googleauthorLee Smith-
dc.contributor.googleauthorJae Il Shin-
dc.identifier.doi10.1002/jmv.27871-
dc.contributor.localIdA02142-
dc.contributor.localIdA02866-
dc.contributor.localIdA04727-
dc.relation.journalcodeJ01587-
dc.identifier.eissn1096-9071-
dc.identifier.pmid35588301-
dc.subject.keywordCOVID-19-
dc.subject.keywordDelta variant-
dc.subject.keywordbreakthrough infection-
dc.subject.keywordclinical manifestations-
dc.subject.keywordvaccine effectiveness-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.contributor.affiliatedAuthor이성수-
dc.contributor.affiliatedAuthor김아영-
dc.citation.volume94-
dc.citation.number9-
dc.citation.startPage4234-
dc.citation.endPage4245-
dc.identifier.bibliographicCitationJOURNAL OF MEDICAL VIROLOGY, Vol.94(9) : 4234-4245, 2022-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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