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CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T Cells by Inhibiting mTOR Pathways
DC Field | Value | Language |
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dc.contributor.author | 김종훈 | - |
dc.date.accessioned | 2022-12-22T04:10:12Z | - |
dc.date.available | 2022-12-22T04:10:12Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192061 | - |
dc.description.abstract | IL-15 induces the proliferation of memory CD8+ T cells as well as NK cells. The expression of CD5 inversely correlates with the IL-15 responsiveness of human memory CD8+ T cells. However, whether CD5 directly regulates IL-15-induced proliferation of human memory CD8+ T cells is unknown. In the current study, we demonstrate that human memory CD8+ T cells in advanced stages of differentiation respond to IL-15 better than human memory CD8+ T cells in stages of less differentiation. We also found that the expression level of CD5 is the best correlate for IL-15 hyporesponsiveness among human memory CD8+ T cells. Importantly, we found that IL-15-induced proliferation of human memory CD8+ T cells is significantly enhanced by blocking CD5 with Abs or knocking down CD5 expression using small interfering RNA, indicating that CD5 directly suppresses the IL-15-induced proliferation of human memory CD8+ T cells. We also found that CD5 inhibits activation of the mTOR pathway, which is required for IL-15-induced proliferation of human memory CD8+ T cells. Taken together, the results indicate that CD5 is not just a correlative marker for IL-15 hyporesponsiveness, but it also directly suppresses IL-15-induced proliferation of human memory CD8+ T cells by inhibiting mTOR pathways. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Association of Immunologists | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | CD5 Antigens* / metabolism | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes* / cytology | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunologic Memory | - |
dc.subject.MESH | Interleukin-15* / immunology | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.subject.MESH | RNA, Small Interfering | - |
dc.subject.MESH | TOR Serine-Threonine Kinases* / metabolism | - |
dc.title | CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T Cells by Inhibiting mTOR Pathways | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Young Joon Choi | - |
dc.contributor.googleauthor | Hoyoung Lee | - |
dc.contributor.googleauthor | Jong Hoon Kim | - |
dc.contributor.googleauthor | So-Young Kim | - |
dc.contributor.googleauthor | June-Young Koh | - |
dc.contributor.googleauthor | Moa Sa | - |
dc.contributor.googleauthor | Su-Hyung Park | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.identifier.doi | 10.4049/jimmunol.2100854 | - |
dc.contributor.localId | A05233 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.pmid | 36002232 | - |
dc.identifier.url | https://journals.aai.org/jimmunol/article/209/6/1108/234180/CD5-Suppresses-IL-15-Induced-Proliferation-of | - |
dc.contributor.alternativeName | Kim, Jong Hoon | - |
dc.contributor.affiliatedAuthor | 김종훈 | - |
dc.citation.volume | 209 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1108 | - |
dc.citation.endPage | 1117 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.209(6) : 1108-1117, 2022-09 | - |
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