Cited 2 times in
Multiple Drilling with Recombinant Human Bone Morphogenetic Protein-2 in Korean Patients with Non-Traumatic Osteonecrosis of the Femoral Head: A Prospective Randomized Pilot Study with a Minimum Two-Year Follow-Up
DC Field | Value | Language |
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dc.contributor.author | 권혁민 | - |
dc.contributor.author | 박관규 | - |
dc.contributor.author | 이우석 | - |
dc.contributor.author | 박준영 | - |
dc.contributor.author | 조병우 | - |
dc.date.accessioned | 2022-12-22T04:07:06Z | - |
dc.date.available | 2022-12-22T04:07:06Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192052 | - |
dc.description.abstract | We sought to determine whether multiple drilling (MD) combined with the injection of recombinant human bone morphogenetic protein-2 (rhBMP-2) and β-tricalcium phosphate (β-TCP) could improve survival of the femoral head in pre-collapse lesions of non-traumatic osteonecrosis of the femoral head (ONFH) as compared with MD alone. We conducted a single-site, off-label, comparative and prospective cohort study between November 2017 and May 2019. We enrolled 25 hips (25 patients) with non-traumatic ONFH (Ficat-Arlet stage 2A or less). We performed a survival analysis, and the primary outcome was the occurrence of femoral head collapse on follow-up radiograph. Our cohort consisted of 11 men and 9 women of age 52.5 ± 8.8 years and a body mass index of 24.3 ± 3.0 kg/m2. The femoral heads were preserved in 9 hips (45.0%) and collapsed in 11 hips (55.0%) at the final follow-up; mean survival to collapse was 6.9 (range 2.8-13.5) months. There were no significant differences in the survival of the femoral head between the MD alone group and the MD with rhBMP-2 and β-TCP group (five hips survived, 50% vs. four hips survived, 40%, respectively; p = 0.83). MD combined with the injection of rhBMP-2 and β-TCP did not improve femoral head survival compared to MD alone in the pre-collapse non-traumatic ONFH lesion. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Multiple Drilling with Recombinant Human Bone Morphogenetic Protein-2 in Korean Patients with Non-Traumatic Osteonecrosis of the Femoral Head: A Prospective Randomized Pilot Study with a Minimum Two-Year Follow-Up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Jun Young Park | - |
dc.contributor.googleauthor | Byung Woo Cho | - |
dc.contributor.googleauthor | Hyuck Min Kwon | - |
dc.contributor.googleauthor | Woo-Suk Lee | - |
dc.contributor.googleauthor | Kwan Kyu Park | - |
dc.identifier.doi | 10.3390/jcm11195499 | - |
dc.contributor.localId | A05086 | - |
dc.contributor.localId | A01428 | - |
dc.contributor.localId | A02992 | - |
dc.contributor.localId | A04940 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 36233365 | - |
dc.subject.keyword | joint-preservation procedure | - |
dc.subject.keyword | multiple drilling | - |
dc.subject.keyword | osteonecrosis of the femoral head | - |
dc.subject.keyword | recombinant bone morphogenetic protein-2 | - |
dc.subject.keyword | β-tricalcium phosphate | - |
dc.contributor.alternativeName | Kwon, Hyuck Min | - |
dc.contributor.affiliatedAuthor | 권혁민 | - |
dc.contributor.affiliatedAuthor | 박관규 | - |
dc.contributor.affiliatedAuthor | 이우석 | - |
dc.contributor.affiliatedAuthor | 박준영 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 5499 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.11(19) : 5499, 2022-09 | - |
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