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Multiple Drilling with Recombinant Human Bone Morphogenetic Protein-2 in Korean Patients with Non-Traumatic Osteonecrosis of the Femoral Head: A Prospective Randomized Pilot Study with a Minimum Two-Year Follow-Up

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dc.contributor.author권혁민-
dc.contributor.author박관규-
dc.contributor.author이우석-
dc.contributor.author박준영-
dc.contributor.author조병우-
dc.date.accessioned2022-12-22T04:07:06Z-
dc.date.available2022-12-22T04:07:06Z-
dc.date.issued2022-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192052-
dc.description.abstractWe sought to determine whether multiple drilling (MD) combined with the injection of recombinant human bone morphogenetic protein-2 (rhBMP-2) and β-tricalcium phosphate (β-TCP) could improve survival of the femoral head in pre-collapse lesions of non-traumatic osteonecrosis of the femoral head (ONFH) as compared with MD alone. We conducted a single-site, off-label, comparative and prospective cohort study between November 2017 and May 2019. We enrolled 25 hips (25 patients) with non-traumatic ONFH (Ficat-Arlet stage 2A or less). We performed a survival analysis, and the primary outcome was the occurrence of femoral head collapse on follow-up radiograph. Our cohort consisted of 11 men and 9 women of age 52.5 ± 8.8 years and a body mass index of 24.3 ± 3.0 kg/m2. The femoral heads were preserved in 9 hips (45.0%) and collapsed in 11 hips (55.0%) at the final follow-up; mean survival to collapse was 6.9 (range 2.8-13.5) months. There were no significant differences in the survival of the femoral head between the MD alone group and the MD with rhBMP-2 and β-TCP group (five hips survived, 50% vs. four hips survived, 40%, respectively; p = 0.83). MD combined with the injection of rhBMP-2 and β-TCP did not improve femoral head survival compared to MD alone in the pre-collapse non-traumatic ONFH lesion.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMultiple Drilling with Recombinant Human Bone Morphogenetic Protein-2 in Korean Patients with Non-Traumatic Osteonecrosis of the Femoral Head: A Prospective Randomized Pilot Study with a Minimum Two-Year Follow-Up-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학교실)-
dc.contributor.googleauthorJun Young Park-
dc.contributor.googleauthorByung Woo Cho-
dc.contributor.googleauthorHyuck Min Kwon-
dc.contributor.googleauthorWoo-Suk Lee-
dc.contributor.googleauthorKwan Kyu Park-
dc.identifier.doi10.3390/jcm11195499-
dc.contributor.localIdA05086-
dc.contributor.localIdA01428-
dc.contributor.localIdA02992-
dc.contributor.localIdA04940-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid36233365-
dc.subject.keywordjoint-preservation procedure-
dc.subject.keywordmultiple drilling-
dc.subject.keywordosteonecrosis of the femoral head-
dc.subject.keywordrecombinant bone morphogenetic protein-2-
dc.subject.keywordβ-tricalcium phosphate-
dc.contributor.alternativeNameKwon, Hyuck Min-
dc.contributor.affiliatedAuthor권혁민-
dc.contributor.affiliatedAuthor박관규-
dc.contributor.affiliatedAuthor이우석-
dc.contributor.affiliatedAuthor박준영-
dc.citation.volume11-
dc.citation.number19-
dc.citation.startPage5499-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.11(19) : 5499, 2022-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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