Cited 4 times in
Prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea
DC Field | Value | Language |
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dc.contributor.author | 박성하 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 이찬주 | - |
dc.contributor.author | 홍남기 | - |
dc.contributor.author | 구철룡 | - |
dc.contributor.author | 윤민재 | - |
dc.date.accessioned | 2022-12-22T04:04:29Z | - |
dc.date.available | 2022-12-22T04:04:29Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0916-9636 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192032 | - |
dc.description.abstract | Approximately 29% of Korean adults have hypertension; however, the prevalence of primary aldosteronism among the hypertensive population is largely unknown. The aim of our study was to evaluate the prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea. We retrospectively analyzed 1173 patients with newly diagnosed or preexisting hypertension who were referred to our tertiary-care hospital between January 2013 and December 2018. Patients were screened for primary aldosteronism with the aldosterone-renin ratio and underwent a saline infusion test for diagnostic confirmation. Adrenal computed tomography and adrenal venous sampling were performed for subtype classification for primary aldosteronism. Among the 1173 patients (mean age, 51.8 years; women, 53.2%), 360 (30.7%) had positive screening-test results, of whom 71 (6.1%) were finally diagnosed with primary aldosteronism. Conclusive subtype differentiation was made in 55 patients, of whom 15 (27%) had an aldosterone-producing adenoma, 4 (7%) had unilateral adrenal hyperplasia, and 36 (66%) had bilateral adrenal hyperplasia. Patients with primary aldosteronism had a higher ambulatory blood pressure, left ventricular mass index, and urinary albumin-to-creatinine ratio than those without. Moreover, the primary aldosteronism group had a higher prevalence of left ventricular hypertrophy and albuminuria than the non-primary aldosteronism group. Primary aldosteronism may be more common (6.1%) among Korean patients with hypertension than generally recognized. Primary aldosteronism was associated with a higher degree and prevalence of target organ damage and a higher blood pressure level. Wide application of screening tests for primary aldosteronism may be beneficial in detecting this potentially curable cause of hypertension. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | HYPERTENSION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aldosterone | - |
dc.subject.MESH | Blood Pressure Monitoring, Ambulatory | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperaldosteronism* / complications | - |
dc.subject.MESH | Hyperaldosteronism* / diagnosis | - |
dc.subject.MESH | Hyperaldosteronism* / epidemiology | - |
dc.subject.MESH | Hyperplasia / complications | - |
dc.subject.MESH | Hypertension* / complications | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Renin | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tertiary Care Centers | - |
dc.title | Prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Minjae Yoon | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Jaehyung Ha | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.identifier.doi | 10.1038/s41440-022-00948-7 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03238 | - |
dc.contributor.localId | A04388 | - |
dc.contributor.localId | A00201 | - |
dc.relation.journalcode | J01017 | - |
dc.identifier.eissn | 1348-4214 | - |
dc.identifier.pmid | 35681044 | - |
dc.identifier.url | https://www.nature.com/articles/s41440-022-00948-7 | - |
dc.subject.keyword | Ambulatory blood pressure monitoring | - |
dc.subject.keyword | Hypertension | - |
dc.subject.keyword | Primary aldosteronism | - |
dc.subject.keyword | Target-organ damage | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 이유미 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.contributor.affiliatedAuthor | 홍남기 | - |
dc.contributor.affiliatedAuthor | 구철룡 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1418 | - |
dc.citation.endPage | 1429 | - |
dc.identifier.bibliographicCitation | HYPERTENSION RESEARCH, Vol.45(9) : 1418-1429, 2022-09 | - |
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