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Usefulness and potential pitfalls of pre-operative PET-CT in patients with endometrial cancer undergoing one- and two-step sentinel lymph node mapping: Do negative findings on PET-CT negativity really indicate node negativity?

Authors
 Yoo-Na Kim  ;  Dahye Lee  ;  Jongtae Cha  ;  Won Jun Kang  ;  Yong Jae Lee  ;  Jung-Yun Lee  ;  Eun Ji Nam  ;  Sunghoon Kim  ;  Young Tae Kim  ;  Sang Wun Kim 
Citation
 GYNECOLOGIC ONCOLOGY, Vol.166(3) : 438-443, 2022-09 
Journal Title
GYNECOLOGIC ONCOLOGY
ISSN
 0090-8258 
Issue Date
2022-09
MeSH
Endometrial Neoplasms* / diagnostic imaging ; Endometrial Neoplasms* / pathology ; Endometrial Neoplasms* / surgery ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes / diagnostic imaging ; Lymph Nodes / pathology ; Lymph Nodes / surgery ; Lymphatic Metastasis / diagnostic imaging ; Lymphatic Metastasis / pathology ; Positron Emission Tomography Computed Tomography / methods ; Sentinel Lymph Node Biopsy / methods ; Sentinel Lymph Node* / diagnostic imaging ; Sentinel Lymph Node* / pathology ; Sentinel Lymph Node* / surgery
Keywords
Endometrial neoplasms ; Lymphatic metastasis ; Positron emission tomography-computed tomography ; Sentinel lymph node biopsy
Abstract
Objective: We investigated the utility of Positron emission tomography-Computed tomography (PET-CT) in the setting of two different sentinel lymph node (SLN) mapping techniques; the conventional cervical injection method (one-step) and the two-step method, which involves fundal injection followed by cervical injection.

Methods: Patients with endometrial cancer undergoing FDG PET-CT followed by laparoscopic or robotic surgical staging with SLN mapping at the Yonsei Cancer Center between July 2014 and April 2021 were stratified into the PET-positive group (with suspected or likely lymph nodes metastasis) and PET-negative group. A chart review was performed for the number of harvested SLNs, patterns of SLN metastases, and recurrence.

Results: Among 466 patients undergoing one-step (n = 276) and two-step (n = 190) SLN mapping, LN metastasis was identified in 21 of 434 PET-negative and 18 of 32 PET-positive patients. The sensitivity and specificity of PET-CT for diagnosing lymph node metastasis were 46.2% and 96.7%, respectively. Among PET-positive patients with LN metastasis, anatomical distribution was concordant in 14/18 patients (77.8%). Among PET-negative patients, four (2.3%) had metastatic para-aortic SLNs, including three (1.7%) with isolated para-aortic metastases; metastatic para-aortic SLNs were exclusively found in the two-step group. Among PET-positive patients, para-aortic SLN metastasis was identified in 35.7% of two-step and 16.7% of one-step group. Among the 21 PET false-negative patients, recurrence was seen in four patients (19%) after a median follow-up of 34 months (range: 7-70 months).

Conclusions: PET-CT served as a useful guide to clinicians with high anatomical concordance rate in patients with LN metastasis. However, despite high specificity, sensitivity was limited. SLN metastasis pattern, especially at the para-aortic level, indicates that the two-step SLN technique might be useful in PET-negative and PET-positive patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S0090825822004875?via%3Dihub
DOI
10.1016/j.ygyno.2022.07.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Yoo‐Na(김유나)
Nam, Eun Ji(남은지) ORCID logo https://orcid.org/0000-0003-0189-3560
Lee, Yong Jae(이용재) ORCID logo https://orcid.org/0000-0003-0297-3116
Lee, Jung-Yun(이정윤) ORCID logo https://orcid.org/0000-0001-7948-1350
Cha, Jongtae(차종태)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192025
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