Cited 3 times in
HLA-A*24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B*58:01 carriers in a Korean population; a multicenter cross-sectional case-control study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양재석 | - |
dc.date.accessioned | 2022-12-22T03:52:10Z | - |
dc.date.available | 2022-12-22T03:52:10Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191994 | - |
dc.description.abstract | Background: HLA-B*58:01 is a well-known risk factor for allopurinol-induced severe cutaneous adverse reactions (SCARs). However, only a minority of HLA-B*58:01 carriers suffer SCARs after taking allopurinol. The aim of this study was to investigate subsidiary genetic markers that could identify those at further increased risk of developing allopurinol-induced drug reaction with eosinophilia and systemic symptoms (DRESS) in subjects with HLA-B*58:01. Methods: Subjects with B*58:01 were enrolled (21 allopurinol-induced DRESS and 52 allopurinol-tolerant control). HLA-A, -B, -C and -DRB1 alleles were compared. Comparison of risk between HLAs and allopurinol-induced SCAR in separate populations was performed to support the results. Kruskal-Wallis test, Pearson's chi-square test, Fisher's exact test and binary logistic regression were used to analyze the risk of SCAR development. Results: Frequencies of A*24:02 (71.4 vs. 17.3%, p < 0.001, odds ratio [OR] = 12.0; 95% confidence interval [CI], 3.6-39.2) were significantly higher in B*58:01 (+) DRESS than B*58:01 (+) tolerant controls. In addition, DRB1*13:02 further increased the risk of DRESS. The phenotype frequency of A*24:02/DRB1*13:02 was significantly higher in the B*58:01 (+) DRESS group than in the B*58:01 (+) tolerant controls (52.4% vs. 5.8%, p < 0.001, OR, 66.0; 95% CI, 6.1-716.2). In 2782 allopurinol user cohort, the overall prevalence of DRESS was 0.22%, which increased to 1.62% and 2.86% in the presence of B*58:01 and B*58:01/A*24:02, respectively. Conclusion: The additional secondary screening with A*24:02 and DRB1*13:02 alleles may identify those at further increased risk of allopurinol-induced DRESS in B*58:01 carriers. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | CLINICAL AND TRANSLATIONAL ALLERGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | HLA-A*24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B*58:01 carriers in a Korean population; a multicenter cross-sectional case-control study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Mi-Yeong Kim | - |
dc.contributor.googleauthor | James Yun | - |
dc.contributor.googleauthor | Dong-Yoon Kang | - |
dc.contributor.googleauthor | Tae Hee Kim | - |
dc.contributor.googleauthor | Min-Kyung Oh | - |
dc.contributor.googleauthor | Sunggun Lee | - |
dc.contributor.googleauthor | Min-Gyu Kang | - |
dc.contributor.googleauthor | Young-Hee Nam | - |
dc.contributor.googleauthor | Jeong-Hee Choi | - |
dc.contributor.googleauthor | Min-Suk Yang | - |
dc.contributor.googleauthor | Seung Seok Han | - |
dc.contributor.googleauthor | Hajeong Lee | - |
dc.contributor.googleauthor | Hyun-Jai Cho | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.contributor.googleauthor | Kook-Hwan Oh | - |
dc.contributor.googleauthor | Yon Su Kim | - |
dc.contributor.googleauthor | Jae Woo Jung | - |
dc.contributor.googleauthor | Kye Hwa Lee | - |
dc.contributor.googleauthor | Hye-Ryun Kang | - |
dc.identifier.doi | 10.1002/clt2.12193 | - |
dc.contributor.localId | A06130 | - |
dc.relation.journalcode | J04154 | - |
dc.identifier.eissn | 2045-7022 | - |
dc.identifier.pmid | 36176736 | - |
dc.subject.keyword | HLA‐A24 antigen | - |
dc.subject.keyword | Koreans | - |
dc.subject.keyword | allopurinol | - |
dc.subject.keyword | drug hypersensitivity syndrome | - |
dc.subject.keyword | histocompatibility antigens class I | - |
dc.contributor.alternativeName | Yang, Jaeseok | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e12193 | - |
dc.identifier.bibliographicCitation | CLINICAL AND TRANSLATIONAL ALLERGY, Vol.12(9) : e12193, 2022-09 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.