Alveolar cleft ; Bone graft ; Materials ; Reconstruction
Abstract
Alveolar cleft is a congenital anomaly with a frequency of 0.18-2.50 per 1,000 births, which invades the bone of maxil lary arch. Iliac crestal bone graft, considered as the gold standard for treatment of alveolar cleft, is a commonly used material due to its abundant mass, ease of harvesting, and the advantages of simultaneous operation with alveolar cleft reconstruction surgery. Despite many advantages of Iliac crestal bone graft, many studies have been conducted on alternative and additional materials for secondary alveolar bone graft in consideration of the disadvantages of iliac crest bone graft. Autogenous bone grafts from other donor sites, such as cranium, mandible and tibia can be used as an alternative with lower morbidity and lower bone resorption. Bone-tissue engineering strategies such as scaffolds, growth factors have also shown promising results in treatment of alveolar cleft. In addition, the use of Platelet-Rich-Fibrin/Plasma with abundant growth factors and osteoinducibility can increase bone maintenance and achieve better results. Therefore, here we review the various bone graft methods used in reconstruction of alveolar cleft.