589 214

Cited 6 times in

In situ diagnosis and simultaneous treatment of cardiac diseases using a single-device platform

DC Field Value Language
dc.contributor.author김남균-
dc.contributor.author이삭-
dc.date.accessioned2022-12-22T03:43:54Z-
dc.date.available2022-12-22T03:43:54Z-
dc.date.issued2022-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191958-
dc.description.abstractThe in situ diagnosis of cardiac activities with simultaneous therapeutic electrical stimulation of the heart is key to preventing cardiac arrhythmia. Here, we present an unconventional single-device platform that enables in situ monitoring even in a wet condition and control of beating heart motions without interferences to the recording signal. This platform consists of the active-matrix array of pressure-sensitive transistors for detecting cardiac beatings, biocompatible, low-impedance electrodes for cardiac stimulations, and an alginate-based hydrogel adhesive for attaching this platform conformally to the epicardium. In contrast to conventional electrophysiological sensing using electrodes, the pressure-sensitive transistors measured mechanophysiological characteristics by monitoring the spatiotemporal distributions of cardiac pressures during heart beating motions. In vivo tests show mechanophysiological readings having good correlation with electrocardiography and negligible interference with the electrical artifacts caused during cardiac stimulations. This platform can therapeutically synchronize the rhythm of abnormal heartbeats through efficient pacing of cardiac arrhythmia.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isPartOfSCIENCE ADVANCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHArrhythmias, Cardiac* / diagnosis-
dc.subject.MESHArrhythmias, Cardiac* / therapy-
dc.subject.MESHElectrocardiography-
dc.subject.MESHElectrodes-
dc.subject.MESHHeart* / diagnostic imaging-
dc.subject.MESHHumans-
dc.subject.MESHMyocardial Contraction-
dc.titleIn situ diagnosis and simultaneous treatment of cardiac diseases using a single-device platform-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthorJae Chul Hwang-
dc.contributor.googleauthorMoohyun Kim-
dc.contributor.googleauthorSumin Kim-
dc.contributor.googleauthorHunkyu Seo-
dc.contributor.googleauthorSoohwan An-
dc.contributor.googleauthorEui Hwa Jang-
dc.contributor.googleauthorSeung Yeop Han-
dc.contributor.googleauthorMi Jung Kim-
dc.contributor.googleauthorNam Kyun Kim-
dc.contributor.googleauthorSeung-Woo Cho-
dc.contributor.googleauthorSak Lee-
dc.contributor.googleauthorJang-Ung Park-
dc.identifier.doi10.1126/sciadv.abq0897-
dc.contributor.localIdA00355-
dc.contributor.localIdA02807-
dc.relation.journalcodeJ03735-
dc.identifier.eissn2375-2548-
dc.identifier.pmid36103536-
dc.contributor.alternativeNameKim, Nam Kyun-
dc.contributor.affiliatedAuthor김남균-
dc.contributor.affiliatedAuthor이삭-
dc.citation.volume8-
dc.citation.number37-
dc.citation.startPageeabq0897-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, Vol.8(37) : eabq0897, 2022-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.