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전이성 대장암의 외과적 치료

Other Titles
 Surgical treatment for metastatic colorectal cancer 
Authors
 박은정  ;  백승혁 
Citation
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, Vol.65(9) : 568-576, 2022-09 
Journal Title
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION(대한의사협회지)
ISSN
 1975-8456 
Issue Date
2022-09
Keywords
Colorectal cancer ; Surgical procedure ; Peritoneal neoplasms ; Neoplasm metastasis
Abstract
Background: Stage IV colorectal cancer (CRC) exhibits heterogeneous characteristics in tumor extent and biology. The overall survival of patients with metastatic CRC has improved with the development of multimodal treatments and new chemotherapeutic drugs.
Current Concepts: Resection of metastatic CRC is performed for liver, lung, or peritoneal metastases. Conversion surgeries to resect oligometastatic lesions have been developed with tumor regression using chemotherapeutic agents. Two-stage hepatectomy has extended the surgical indications for patients with metastatic CRC. Synchronous liver and primary tumor resection can be considered in patients with adequate conditions. Local ablation with radiotherapy can be used to treat lung metastasis. Meanwhile, for treating patients with CRC with peritoneal metastasis, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy can be considered. Surgical treatments should be performed in patients with symptomatic primary tumors with unresectable metastasis. However, in recent studies, primary tumor resection in patients with asymptomatic CRC with synchronous, unresectable metastases did not show overall survival benefits.
Discussion and Conclusion: The treatment of metastatic CRC is challenging because of the variable tumor extent and heterogenous characteristics. Tailored surgical treatments and multidisciplinary approaches may improve the survival and quality of life of patients with metastatic CRC.
Files in This Item:
T202204663.pdf Download
DOI
10.5124/jkma.2022.65.9.568
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun Jung(박은정) ORCID logo https://orcid.org/0000-0002-4559-2690
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191947
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