Cited 1 times in
Impact of Severe Hypercholesterolemia on Cardiovascular Risk in Individuals With or Without Diabetes Mellitus
DC Field | Value | Language |
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dc.contributor.author | 이상학 | - |
dc.contributor.author | 이찬주 | - |
dc.date.accessioned | 2022-12-22T03:40:48Z | - |
dc.date.available | 2022-12-22T03:40:48Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2287-2892 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191943 | - |
dc.description.abstract | Objective: The aim of the current study was to investigate whether the impact of low-density lipoprotein-cholesterol (LDL-C) levels on cardiovascular risk is different between individuals with severe hypercholesterolemia and diabetes mellitus (DM) and those without DM. Methods: This study used the database of a National Health Insurance Service cohort of Korea. Among individuals who underwent health check-up, 2,261,332 were included and categorized into 3 groups with severe hypercholesterolemia, >260, 225-259, and 190-224 mg/dL groups, and a control group (<160 mg/dL). Risks of composite events (myocardial infarction [MI], coronary revascularization, and ischemic stroke) and total mortality were analyzed, according to the presence of DM. Results: Of the study population, 5.2% had DM. During median follow-up of 6.1 years, the rates of composite events (/1,000 person-year) in non-DM and DM subjects were up to 5.66 and 8.92, respectively. Adjusted hazard ratios (aHRs) of the composite events ranged up to 3.11 and 1.44 in non-DM and DM groups, respectively (p<0.0001 between LDL-C categories in both groups). Dependency of aHR on LDL-C levels was more prominent in the non-DM group. aHRs of MI and coronary revascularization showed similar tendency to the composite events. Although aHRs of ischemic stroke (p<0.0001) and total mortality (p=0.002) were different according to LDL-C categories in the non-DM group, these relations were not observed in DM group. Conclusion: Although individuals with severe hypercholesterolemia had high cardiovascular risk when DM was present, the impact of LDL-C on the risk was attenuated in this population. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 한국지질동맥경화학회 | - |
dc.relation.isPartOf | Journal of Lipid and Atherosclerosis | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Impact of Severe Hypercholesterolemia on Cardiovascular Risk in Individuals With or Without Diabetes Mellitus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Sanghyun Park | - |
dc.contributor.googleauthor | Kyungdo Han | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.identifier.doi | 10.12997/jla.2022.11.3.299 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03238 | - |
dc.relation.journalcode | J01562 | - |
dc.identifier.eissn | 2288-2561 | - |
dc.identifier.pmid | 36212745 | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Diabetes mellitus, type 2 | - |
dc.subject.keyword | Hyperlipoproteinemia type II | - |
dc.subject.keyword | Outcome assessment, health care | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 299 | - |
dc.citation.endPage | 307 | - |
dc.identifier.bibliographicCitation | Journal of Lipid and Atherosclerosis, Vol.11(3) : 299-307, 2022-09 | - |
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