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Nosocomial outbreak of Achromobacter spp. bacteremia due to germicide contamination: a systematic review

Authors
 S H Yoon  ;  H Kim  ;  S M Lim  ;  J-M Kang 
Citation
 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol.26(17) : 6374-6381, 2022-09 
Journal Title
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
ISSN
 1128-3602 
Issue Date
2022-09
MeSH
Achromobacter* ; Anti-Infective Agents* ; Anti-Infective Agents, Local* ; Bacteremia* / epidemiology ; Chlorhexidine ; Cross Infection* / epidemiology ; Disease Outbreaks ; Disinfectants* ; Hospitals ; Humans
Abstract
Objective: Achromobacter spp. are aerobic, non-fermentative Gram-negative bacilli that can be widely found in aquatic environments. Nosocomial outbreaks and pseudo-outbreaks of Achromobacter spp. bacteremia have been recognized for decades. Notably, commonly used germicides in hospital settings constitute important sources for these outbreaks. This review aims at summarizing the latest studies and presents the characteristics of nosocomial outbreaks of Achromobacter spp. bacteremia caused by germicide contamination.

Materials and methods: A systematic search of the PubMed and EMBASE databases was conducted for articles published in English between January 1, 2000, and June 10, 2022.

Results: Overall, 170 articles were retrieved, and 7 studies were finally included in the systematic review. Whether true or pseudo-bacteremia, positive blood culture results were most commonly reported in immunosuppressed patients or those with indwelling catheters. The most commonly reported contaminated germicide was chlorhexidine solution used as both an antiseptic and disinfectant. Atomizers, dispensers, and various product containers were identified as reservoirs. The prognoses of the affected patients were generally favorable.

Conclusions: Awareness about the high survival ability of Achromobacter spp. in germicides and the possible hospital reservoirs of these microbes will help to improve infection control and prevent nosocomial outbreaks or pseudo-outbreaks caused by Achromobacter spp.
Files in This Item:
T202204241.pdf Download
DOI
10.26355/eurrev_202209_29664
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ji-Man(강지만) ORCID logo https://orcid.org/0000-0002-0678-4964
Yoon, Seo Hee(윤서희) ORCID logo https://orcid.org/0000-0002-8361-9815
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191928
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