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Cited 2 times in

Prenatal Diagnosis of Congenital Heart Diseases and Associations with Serum Biomarkers of Aneuploidy: A Multicenter Prospective Cohort Study

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dc.contributor.author이준호-
dc.date.accessioned2022-12-22T03:35:55Z-
dc.date.available2022-12-22T03:35:55Z-
dc.date.issued2022-08-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191912-
dc.description.abstractPurpose: We assessed prenatal detection rates of congenital heart disease (CHD) and associations between maternal serum biomarkers and non-chromosomal CHD in singleton pregnancies. Materials and methods: This study was conducted as a secondary analysis of data obtained during a multicenter prospective cohort study that investigated the cost-effectiveness of prenatal testing for fetal aneuploidy. We analyzed the prenatal detection rate and accuracy for CHD screening via ultrasound during the second trimester, as well as associations between serum biomarkers and CHDs, in singleton newborns without chromosomal abnormalities. Results: Among 6715 women, 142 (2.1%) newborns were born with CHDs, of which 67 (1.0%) newborns had major CHDs. The prenatal detection rate for all CHDs and major CHDs were 34.5% and 58.2%, respectively. After excluding isolated ventricular septal defects, the detection rate for critical CHDs was 85.9%. Women with low pregnancy-associated plasma protein A (PAPP-A) (<0.4 multiples of the median, MOM) face increased risks of non-chromosomal CHDs [adjusted odds ratio (aOR) 2.76; 95% confidence interval (CI) 1.36-5.13] and major CHDs (aOR 7.30; 95% CI 3.18-15.59), compared to those without CHDs. A higher inhibin A level (≥2.5 MOM; aOR 4.84; 95% CI 1.42-12.46) was associated with non-chromosomal major CHDs. Conclusion: Ultrasonography performed during the second trimester by obstetricians detected over 85% of critical CHDs. Low maternal serum PAPP-A or high inhibin-A was associated with non-chromosomal CHDs. These results may contribute to an improvement in prenatal diagnosis of CHDs.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAneuploidy-
dc.subject.MESHBiomarkers-
dc.subject.MESHFemale-
dc.subject.MESHHeart Defects, Congenital* / diagnostic imaging-
dc.subject.MESHHeart Defects, Congenital* / genetics-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHInhibins-
dc.subject.MESHPregnancy-
dc.subject.MESHPregnancy-Associated Plasma Protein-A* / analysis-
dc.subject.MESHPrenatal Diagnosis / methods-
dc.subject.MESHProspective Studies-
dc.subject.MESHUltrasonography, Prenatal-
dc.titlePrenatal Diagnosis of Congenital Heart Diseases and Associations with Serum Biomarkers of Aneuploidy: A Multicenter Prospective Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorJeong Ha Wie-
dc.contributor.googleauthorYou Jung Han-
dc.contributor.googleauthorSoo Hyun Kim-
dc.contributor.googleauthorMoon Young Kim-
dc.contributor.googleauthorHee Young Cho-
dc.contributor.googleauthorMi-Young Lee-
dc.contributor.googleauthorJin Hoon Chung-
dc.contributor.googleauthorSeung Mi Lee-
dc.contributor.googleauthorSoo-Young Oh-
dc.contributor.googleauthorJoon Ho Lee-
dc.contributor.googleauthorHye Yeon Boo-
dc.contributor.googleauthorGeum Joon Cho-
dc.contributor.googleauthorHan-Sung Kwon-
dc.contributor.googleauthorByoung Jae Kim-
dc.contributor.googleauthorMi Hye Park-
dc.contributor.googleauthorHyun Mee Ryu-
dc.contributor.googleauthorHyun Sun Ko-
dc.identifier.doi10.3349/ymj.2022.63.8.735-
dc.contributor.localIdA04846-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid35914755-
dc.subject.keywordCongenital heart disease-
dc.subject.keywordinhibin A-
dc.subject.keywordpregnancy-associated plasma protein-A-
dc.subject.keywordprenatal diagnosis ultrasonic-
dc.subject.keywordsecond-trimester screening-
dc.contributor.alternativeNameLee, Joon Ho-
dc.contributor.affiliatedAuthor이준호-
dc.citation.volume63-
dc.citation.number8-
dc.citation.startPage735-
dc.citation.endPage743-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.63(8) : 735-743, 2022-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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