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Association of blood pressure with cardiovascular outcome and mortality: results from the KNOW-CKD study

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dc.contributor.author강신욱-
dc.contributor.author유태현-
dc.contributor.author윤해룡-
dc.contributor.author주영수-
dc.contributor.author한승혁-
dc.contributor.author박정탁-
dc.date.accessioned2022-12-22T03:26:24Z-
dc.date.available2022-12-22T03:26:24Z-
dc.date.issued2022-08-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191881-
dc.description.abstractBackground: Optimal blood pressure (BP) control is a major therapeutic strategy to reduce adverse cardiovascular events (CVEs) and mortality in patients with chronic kidney disease (CKD). We studied the association of BP with adverse cardiovascular outcome and all-cause death in patients with CKD. Methods: Among 2238 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD), 2226 patients with baseline BP measurements were enrolled. The main predictor was systolic BP (SBP) categorized by five levels: <110, 110-119, 120-129, 130-139 and ≥140 mmHg. The primary endpoint was a composite outcome of all-cause death or incident CVEs. We primarily used marginal structural models (MSMs) using averaged and the most recent time-updated SBPs. Results: During the follow-up of 10 233.79 person-years (median 4.60 years), the primary composite outcome occurred in 240 (10.8%) participants, with a corresponding incidence rate of 23.5 [95% confidence interval (CI) 20.7-26.6]/1000 patient-years. MSMs with averaged SBP showed a U-shaped relationship with the primary outcome. Compared with time-updated SBP of 110-119 mmHg, hazard ratios (95% CI) for <110, 120-129, 130-139 and ≥140 mmHg were 2.47 (1.48-4.11), 1.29 (0.80-2.08), 2.15 (1.26-3.69) and 2.19 (1.19-4.01), respectively. MSMs with the most recent SBP also showed similar findings. Conclusions: In Korean patients with CKD, there was a U-shaped association of SBP with the risk of adverse clinical outcomes. Our findings highlight the importance of BP control and suggest a potential hazard of SBP <110 mmHg.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNEPHROLOGY DIALYSIS TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBlood Pressure-
dc.subject.MESHCardiovascular Diseases* / complications-
dc.subject.MESHCardiovascular Diseases* / etiology-
dc.subject.MESHCohort Studies-
dc.subject.MESHHumans-
dc.subject.MESHHypertension*-
dc.subject.MESHRenal Insufficiency, Chronic*-
dc.subject.MESHRisk Factors-
dc.titleAssociation of blood pressure with cardiovascular outcome and mortality: results from the KNOW-CKD study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJee Young Lee-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorYoung Su Joo-
dc.contributor.googleauthorChanghyun Lee-
dc.contributor.googleauthorHae-Ryong Yun-
dc.contributor.googleauthorTae Ik Chang-
dc.contributor.googleauthorYeong-Hoon Kim-
dc.contributor.googleauthorWooKyung Chung-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorSue K Park-
dc.contributor.googleauthorDong Wan Chae-
dc.contributor.googleauthorKook-Hwan Oh-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1093/ndt/gfab257-
dc.contributor.localIdA00053-
dc.contributor.localIdA02526-
dc.contributor.localIdA04617-
dc.contributor.localIdA03956-
dc.contributor.localIdA04304-
dc.contributor.localIdA01654-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid34473286-
dc.identifier.urlhttps://academic.oup.com/ndt/article/37/9/1722/6362901?login=true-
dc.subject.keywordCKD-
dc.subject.keywordSBP-
dc.subject.keywordcardiovascular outcome-
dc.subject.keywordhypertension-
dc.subject.keywordmortality-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthor강신욱-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor윤해룡-
dc.contributor.affiliatedAuthor주영수-
dc.contributor.affiliatedAuthor한승혁-
dc.contributor.affiliatedAuthor박정탁-
dc.citation.volume37-
dc.citation.number9-
dc.citation.startPage1,722-
dc.citation.endPage1,730-
dc.identifier.bibliographicCitationNEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.37(9) : 1,722-1,730, 2022-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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