Cited 3 times in
Association of Gender With Clinical Outcomes in a Contemporary Cohort of Patients With Atrial Fibrillation Receiving Oral Anticoagulants
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2022-12-22T03:25:44Z | - |
dc.date.available | 2022-12-22T03:25:44Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191875 | - |
dc.description.abstract | Background and objectives: In patients with atrial fibrillation (AF), females taking vitamin K antagonist are at higher risk of stroke or systemic embolism (SSE), bleeding and all-cause death than males. This study investigated the relationship between sex and adverse clinical events in a contemporary AF patient cohort taking anticoagulation. Methods: This prospective multicenter AF registry study comprised 6,067 patients with AF (mean age, 70±9 years; men, 59%) with intermediate to high risk of stroke (CHA2DS2-VAscore ≥1) and receiving oral anticoagulation therapy. Adverse clinical outcomes, including SSE, bleeding, death were evaluated in patients stratified by sex and anticoagulation patterns. Results: Women were older and used more direct oral anticoagulants (85% vs. 78%, p<0.001) than men. During a median (25th and 75th percentiles) follow-up of 30 (24, 38) months, the incidence rate and risk of SSE (0.7 in women vs. 0.7 in men per 100 person-years) and major bleeding (0.1 in women vs. 0.1 in men per 100 person-years) were not different between the sexes. However, women had a lower all-cause death rate (0.4 in women vs. 0.6 in men per 100 person-years, hazard ratio: 0.48, 95% confidence interval: 0.25-0.91, p=0.025) than men. Conclusions: In contemporary anticoagulation for AF, SSE and major bleeding risks did not differ between sexes. However, women showed a lower risk of all-cause death rate than men, indicating that the use of oral anticoagulants for treating AF in females does not appear to be a risk factor for adverse clinical events. Trial registration: ClinicalTrials.gov Identifier: NCT02786095. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association of Gender With Clinical Outcomes in a Contemporary Cohort of Patients With Atrial Fibrillation Receiving Oral Anticoagulants | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Minjeong Kim | - |
dc.contributor.googleauthor | Jun Kim | - |
dc.contributor.googleauthor | Jin-Bae Kim | - |
dc.contributor.googleauthor | Junbeom Park | - |
dc.contributor.googleauthor | Jin-Kyu Park | - |
dc.contributor.googleauthor | Ki-Woon Kang | - |
dc.contributor.googleauthor | Jaemin Shim | - |
dc.contributor.googleauthor | Eue-Keun Choi | - |
dc.contributor.googleauthor | Young Soo Lee | - |
dc.contributor.googleauthor | Hyung Wook Park | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.4070/kcj.2021.0399 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 35656931 | - |
dc.subject.keyword | Anticoagulants | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | Female | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 52 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 593 | - |
dc.citation.endPage | 603 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.52(8) : 593-603, 2022-08 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.