Cited 4 times in

Prognostic Implications of Biventricular Global Longitudinal Strain in Patients With Severe Isolated Tricuspid Regurgitation

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dc.contributor.author서지원-
dc.contributor.author이승현-
dc.contributor.author하종원-
dc.contributor.author홍그루-
dc.contributor.author조익성-
dc.contributor.author심지영-
dc.contributor.author이삭-
dc.date.accessioned2022-12-22T03:09:37Z-
dc.date.available2022-12-22T03:09:37Z-
dc.date.issued2022-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191810-
dc.description.abstractBackground: Isolated TV surgery can be performed in patients with symptoms caused by severe isolated tricuspid regurgitation (TR), preferably before the onset of significant right ventricular (RV) dysfunction. In patients with severe TR, intrinsic RV dysfunction tends to be masked and promotes left ventricular (LV) mechanical dysfunction. This study investigated the prognostic implications of biventricular global longitudinal strain (GLS) in patients receiving isolated tricuspid valve (TV) surgery. Methods: Among 1,670 patients who underwent TV surgery between January 2000 and December 2020, 111 patients with severe isolated TR who underwent echocardiography before and after TV surgery were analyzed. We assessed LV, RV, and biventricular GLS using speckle tracking echocardiography. Biventricular GLS was defined as the sum of LV-GLS and RV free-wall strain. The primary outcomes were cardiovascular death, heart failure hospitalization, re-done TV surgery, and heart transplantation. Results: During 3.9 ± 3.8 years of follow-up after the postoperative echocardiography, 24 (21.6%) patients experienced a primary outcome. Those patients had more comorbidities and more impaired preoperative RV-GLS and biventricular GLS than those who did not experience a primary outcome, although the two groups did not differ in preoperative LV-GLS. Patients with a primary outcome also showed significantly impaired postoperative RV-GLS, biventricular GLS, and LV-GLS compared those without a primary outcome. In multivariate analyses, both pre- and postoperatively assessed RV-GLS [preoperative; hazard ratio (HR) 0.86, confidence interval (CI) 0.79-0.93, p < 0.001, postoperative; HR 0.89, CI 0.82-0.96, p = 0.004] and biventricular GLS [preoperative; HR 0.96, CI 0.91-1.00, p = 0.048, postoperative; HR 0.94, CI 0.89-0.99, p = 0.023] were independently associated with the primary outcomes. Conclusion: In patients with severe isolated TR undergoing TV surgery, the absolute value of RV-GLS under 17.2% is closely associated with a poor prognosis, and that of biventricular GLS under 34.0%, mainly depending on the RV-GLS, is related to the poor prognosis. Further prospective multicenter studies are warranted to establish the risk stratification of isolated TV surgery.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Media S.A.-
dc.relation.isPartOfFRONTIERS IN CARDIOVASCULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrognostic Implications of Biventricular Global Longitudinal Strain in Patients With Severe Isolated Tricuspid Regurgitation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDae-Young Kim-
dc.contributor.googleauthorJiwon Seo-
dc.contributor.googleauthorIksung Cho-
dc.contributor.googleauthorSeung Hyun Lee-
dc.contributor.googleauthorSak Lee-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorChi Young Shim-
dc.identifier.doi10.3389/fcvm.2022.908062-
dc.contributor.localIdA01913-
dc.contributor.localIdA02935-
dc.contributor.localIdA04257-
dc.contributor.localIdA04386-
dc.contributor.localIdA03888-
dc.contributor.localIdA02213-
dc.contributor.localIdA02807-
dc.relation.journalcodeJ04002-
dc.identifier.eissn2297-055X-
dc.identifier.pmid35990943-
dc.subject.keywordglobal longitudinal strain-
dc.subject.keywordisolated tricuspid regurgitation-
dc.subject.keywordleft ventricle-
dc.subject.keywordprognosis-
dc.subject.keywordright ventricle-
dc.subject.keywordsurgery-
dc.contributor.alternativeNameSeo, Ji Won-
dc.contributor.affiliatedAuthor서지원-
dc.contributor.affiliatedAuthor이승현-
dc.contributor.affiliatedAuthor하종원-
dc.contributor.affiliatedAuthor홍그루-
dc.contributor.affiliatedAuthor조익성-
dc.contributor.affiliatedAuthor심지영-
dc.contributor.affiliatedAuthor이삭-
dc.citation.volume9-
dc.citation.startPage908062-
dc.identifier.bibliographicCitationFRONTIERS IN CARDIOVASCULAR MEDICINE, Vol.9 : 908062, 2022-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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