Cited 11 times in
Emerging role of anti-proliferative protein BTG1 and BTG2
DC Field | Value | Language |
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dc.contributor.author | 황수석 | - |
dc.contributor.author | 황수석 | - |
dc.date.accessioned | 2022-12-22T03:02:28Z | - |
dc.date.available | 2022-12-22T03:02:28Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191782 | - |
dc.description.abstract | The B cell translocation gene 1 (BTG1) and BTG2 play a key role in a wide range of cellular activities including proliferation, apoptosis, and cell growth via modulating a variety of central biological steps such as transcription, post-transcriptional, and translation. BTG1 and BTG2 have been identified by genomic profiling of B-cell leukemia and diverse lymphoma types where both genes are commonly mutated, implying that they serve as tumor suppressors. Furthermore, a low expression level of BTG1 or BTG2 in solid tumors is frequently associated with malignant progression and poor treatment outcomes. As physiological aspects, BTG1 and BTG2 have been discovered to play a critical function in regulating quiescence in hematopoietic lineage such as Hematopoietic stem cells (HSCs) and naïve and memory T cells, highlighting their novel role in maintaining the quiescent state. Taken together, emerging evidence from the recent studies suggests that BTG1 and BTG2 play a central anti-proliferative role in various tissues and cells, indicating their potential as targets for innovative therapeutics. [BMB Reports 2022; 55(8): 380-388]. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Society for Biochemistry and Molecular Biology | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cell Cycle | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immediate-Early Proteins* / genetics | - |
dc.subject.MESH | Immediate-Early Proteins* / metabolism | - |
dc.subject.MESH | Neoplasm Proteins* / genetics | - |
dc.subject.MESH | Neoplasms* / genetics | - |
dc.subject.MESH | Tumor Suppressor Proteins* / genetics | - |
dc.subject.MESH | Tumor Suppressor Proteins* / metabolism | - |
dc.title | Emerging role of anti-proliferative protein BTG1 and BTG2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.googleauthor | Sang Hyeon Kim | - |
dc.contributor.googleauthor | In Ryeong Jung | - |
dc.contributor.googleauthor | Soo Seok Hwang | - |
dc.identifier.doi | 10.5483/BMBRep.2022.55.8.092 | - |
dc.contributor.localId | A06349 | - |
dc.relation.journalcode | J00348 | - |
dc.identifier.eissn | 1976-670X | - |
dc.identifier.pmid | 35880434 | - |
dc.contributor.alternativeName | Hwang, Soo Seok | - |
dc.contributor.affiliatedAuthor | 황수석 | - |
dc.citation.volume | 55 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 380 | - |
dc.citation.endPage | 388 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, Vol.55(8) : 380-388, 2022-08 | - |
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