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Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice
DC Field | Value | Language |
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dc.contributor.author | 김재우 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 서다혜 | - |
dc.contributor.author | 박세은 | - |
dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2022-12-22T02:54:59Z | - |
dc.date.available | 2022-12-22T02:54:59Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191736 | - |
dc.description.abstract | Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE3) that increases intracellular cyclic adenosine monophosphate (cAMP), which plays a critical role in the development of the beige phenotype and the activation of its thermogenic program in white adipose tissue (WAT). We investigated the metabolic effects of PDE3B inhibition with cilostazol treatment in the adipose tissue of high-fat diet (HFD)-fed mice. Seven-week-old male C57BL/6J mice were randomly assigned to either the cilostazol or control group. The control group was divided into two groups: the chow diet and HFD. The expression of uncoupling Protein 1 (UCP1) and other brown adipocyte markers was compared. In the HFD-fed cilostazol group, C57BL/6J mice displayed improvements in systemic metabolism, including improved glucose tolerance and lipid profile, but only modest effects on body weight were observed. In the visceral WAT of HFD-fed cilostazol-treated mice, cAMP/protein kinase A (PKA) signaling pathways were activated, resulting in the "browning" phenotype, smaller fat deposits, and enhanced mRNA expression of UCP1 and other brown adipocyte markers. PDE3B appears to be an important regulator of lipid metabolism, insulin sensitivity, and thermogenic programs in adipose tissues. An increase in intracellular cAMP via PDE3B inhibition with cilostazol treatment promoted the browning of visceral WAT. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | BIOMEDICINES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.googleauthor | Da Hea Seo | - |
dc.contributor.googleauthor | Eugene Shin | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Se-Eun Park | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Jae-Woo Kim | - |
dc.contributor.googleauthor | Bong-Soo Cha | - |
dc.identifier.doi | 10.3390/biomedicines 10081852 | - |
dc.contributor.localId | A00865 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J03914 | - |
dc.identifier.eissn | 2227-9059 | - |
dc.identifier.pmid | 36009398 | - |
dc.subject.keyword | beige adipose tissue | - |
dc.subject.keyword | cilostazol | - |
dc.subject.keyword | white adipose tissue | - |
dc.contributor.alternativeName | Kim, Jae Woo | - |
dc.contributor.affiliatedAuthor | 김재우 | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.contributor.affiliatedAuthor | 차봉수 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1852 | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, Vol.10(8) : 1852, 2022-08 | - |
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