Design and Methods of a Prospective Smartphone App-Based Study for Digital Phenotyping of Mood and Anxiety Symptoms Mixed With Centralized and Decentralized Research Form: The Search Your Mind (SYM, ?) Project

Abstract

In this study, the Search Your Mind (S.Y.M., ???) project aimed to collect prospective digital phenotypic data centered on mood and anxi-ety symptoms across psychiatric disorders through a smartphone application (app) platform while using both centralized and decentral-ized research designs: the centralized research design is a hybrid of a general prospective observational study and a digital platform-based study, and it includes face-to-face research such as informed written consent, clinical evaluation, and blood sampling. It also includes digi-tal phenotypic assessment through an application-based platform using wearable devices. Meanwhile, the decentralized research design is a non-face-to-face study in which anonymous participants agree to electronic informed consent forms on the app. It also exclusively uses an application-based platform to acquire individualized digital phenotypic data. We expect to collect clinical, biological, and digital phe-notypic data centered on mood and anxiety symptoms, and we propose a possible model of centralized and decentralized research design.