Cited 6 times in
Left Ventricular Diastolic Dysfunction and Progression of Chronic Kidney Disease: Analysis of KNOW-CKD Data
DC Field | Value | Language |
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dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2022-12-22T02:48:06Z | - |
dc.date.available | 2022-12-22T02:48:06Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191696 | - |
dc.description.abstract | Background Few studies have examined the association between the early diastolic mitral inflow velocity/early diastolic mitral annulus velocity ratio (E/e') and chronic kidney disease progression. Methods and Results We reviewed data from 2238 patients with nondialysis chronic kidney disease from the KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease); data from 163 patients were excluded because of missing content. A >50% decrease in estimated glomerular filtration rate from baseline, doubling of serum creatinine, or dialysis initiation and/or kidney transplantation were considered renal events. At baseline, median (interquartile range) ejection fraction and E/e' were 64.0% (60.0%-68.0%) and 9.1 (7.4-11.9), respectively. Proportions of ejection fraction <50% and E/e' ≥15 were 1.3% and 9.6%, respectively. More than one quarter of patients (27.2%) had an estimated glomerular filtration rate <30 mL/min per 1.73 m2. During the mean 59.1-month follow-up period, 724 patients (34.9%) experienced renal events. In multivariable Cox proportional hazard regression analysis, the hazard ratio with 95% CI per 1-unit increase in E/e' was 1.027 (1.005-1.050; P=0.016). Penalized spline curve analysis yielded a suggested threshold of E/e' for renal events of 12; in our data set, the proportion of E/e' ≥12 was 4.1%. Conclusions Increased E/e' was associated with an increased hazard of renal events, suggesting that diastolic heart dysfunction is a novel risk factor for chronic kidney disease progression. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diastole | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / complications | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / diagnosis | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / epidemiology | - |
dc.subject.MESH | Ventricular Dysfunction, Left* / etiology | - |
dc.subject.MESH | Ventricular Function, Left | - |
dc.title | Left Ventricular Diastolic Dysfunction and Progression of Chronic Kidney Disease: Analysis of KNOW-CKD Data | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Eunjeong Kang | - |
dc.contributor.googleauthor | Sung Woo Lee | - |
dc.contributor.googleauthor | Hyunjin Ryu | - |
dc.contributor.googleauthor | Minjung Kang | - |
dc.contributor.googleauthor | Seonmi Kim | - |
dc.contributor.googleauthor | Sue K Park | - |
dc.contributor.googleauthor | Ji Yong Jung | - |
dc.contributor.googleauthor | Kyu-Beck Lee | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Curie Ahn | - |
dc.contributor.googleauthor | Kook-Hwan Oh | - |
dc.identifier.doi | 10.1161/JAHA.122.025554 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J01774 | - |
dc.identifier.eissn | 2047-9980 | - |
dc.identifier.pmid | 35766277 | - |
dc.subject.keyword | cardiorenal syndrome | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | diastolic heart dysfunction | - |
dc.subject.keyword | early predictor | - |
dc.subject.keyword | progression | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | e025554 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.11(13) : e025554, 2022-07 | - |
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