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Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 김덕기 | - |
dc.date.accessioned | 2022-12-22T02:45:38Z | - |
dc.date.available | 2022-12-22T02:45:38Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191680 | - |
dc.description.abstract | Chronic kidney disease (CKD) is a critical complication of liver transplants, of which non-renal risk factors are not fully understood yet. This study aimed to reveal pre- and post-transplant risk factors for CKD (<60 mL/min/1.73 m2), examining liver recipients with functionally intact kidneys one month after grafting using nationwide cohort data. Baseline risk factors were analyzed with multivariable Cox regression analyses and post-transplant risk factors were investigated with the time-dependent Cox model and matched analyses of time-conditional propensity scores. Of the 2274 recipients with a one-month eGFR ≥ 60 mL/min/1.73 m2, 494 (22.3%) developed CKD during a mean follow-up of 36.6 ± 14.4 months. Age, female sex, lower body mass index, pre-transplant diabetes mellitus, and lower performance status emerged as baseline risk factors for CKD. Time-dependent Cox analyses revealed that recurrent hepatocellular carcinoma (HR = 1.93, 95% CI 1.06-3.53) and infection (HR = 1.44, 95% CI 1.12-1.60) were significant post-transplant risk factors for CKD. Patients who experienced one of those factors showed a significantly higher risk of subsequent CKD compared with the matched controls who lacked these features (p = 0.013 for recurrent hepatocellular carcinoma, and p = 0.003 for infection, respectively). This study clarifies pre- and post-transplant non-renal risk factors, which lead to renal impairment after LT independently from patients' renal functional reserve. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Deok-Gie Kim | - |
dc.contributor.googleauthor | Shin Hwang | - |
dc.contributor.googleauthor | Jong Man Kim | - |
dc.contributor.googleauthor | Je Ho Ryu | - |
dc.contributor.googleauthor | Young Kyoung You | - |
dc.contributor.googleauthor | Donglak Choi | - |
dc.contributor.googleauthor | Bong-Wan Kim | - |
dc.contributor.googleauthor | Dong-Sik Kim | - |
dc.contributor.googleauthor | Yang Won Nah | - |
dc.contributor.googleauthor | Tae-Seok Kim | - |
dc.contributor.googleauthor | Jai Young Cho | - |
dc.contributor.googleauthor | Geun Hong | - |
dc.contributor.googleauthor | Jae Do Yang | - |
dc.contributor.googleauthor | Jaryung Han | - |
dc.contributor.googleauthor | Suk-Won Suh | - |
dc.contributor.googleauthor | Kwan Woo Kim | - |
dc.contributor.googleauthor | Yun Kyung Jung | - |
dc.contributor.googleauthor | Ju Ik Moon | - |
dc.contributor.googleauthor | Jun Young Lee | - |
dc.contributor.googleauthor | Sung Hwa Kim | - |
dc.contributor.googleauthor | Jae Geun Lee | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Kwang-Woong Lee | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.identifier.doi | 10.3390/jcm11144203 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03948 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 35887972 | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | liver transplantation | - |
dc.subject.keyword | renal dysfunction | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 이재근 | - |
dc.contributor.affiliatedAuthor | 주동진 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 4203 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.11(14) : 4203, 2022-07 | - |
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