0 223

Cited 9 times in

Dynamics of Circulating Immune Cells During Chemoradiotherapy in Patients with Non-Small Cell Lung Cancer Support Earlier Administration of Anti-PD-1/PD-L1 Therapy

DC Field Value Language
dc.contributor.author윤홍인-
dc.contributor.author김경환-
dc.date.accessioned2022-12-22T02:23:41Z-
dc.date.available2022-12-22T02:23:41Z-
dc.date.issued2022-06-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191562-
dc.description.abstractPurpose: Chemoradiotherapy (CRT) followed by consolidation immune checkpoint inhibitors significantly improves survival in unresectable locally advanced non-small cell lung cancer. However, the optimal sequence for CRT and immune checkpoint inhibitors has not yet been established. We investigated the dynamics of peripheral blood immune cells during CRT to determine the best sequence for treatment. Methods and materials: Peripheral blood samples were prospectively collected pretreatment, weekly during CRT for 6 weeks, and 1 month posttreatment in 24 patients with locally advanced non-small cell lung cancer who received definitive CRT. Immune cell analysis was performed by flow cytometry. Ex vivo PD-1 blockade assays were performed by IFN-γ intracellular cytokine staining. Results: Lymphopenia was prominently observed during CRT and mostly recovered 1 month post-CRT. Robust proliferation of CD8+ T cells was induced, peaking in the last week during CRT and decreasing post-CRT. The robust proliferation of CD8+ T cells led to an increase in the frequency of CD28-CD57+ replicative senescent and terminally differentiated cells post-CRT. Tumor-reactive CD8+ T cells increased during CRT and peaked in the last week. One month post-CRT, the frequency of tumor-reactive CD8+ T cells decreased and TOXhiTCF1lo terminally exhausted CD8+ T cells significantly increased. Anti-PD-1-induced functional restoration of PD-1+CD8+ T cells was maximized in the last week of CRT and significantly decreased post-CRT. Conclusions: The findings suggest that earlier administration of PD-1 blockade may be associated with superior efficacy compared with delayed administration after completion of CRT. These findings provide an immunologic rationale for optimal timing of combining immune checkpoint inhibitors with CRT in clinical trials.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Inc.-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHB7-H1 Antigen / therapeutic use-
dc.subject.MESHCD8-Positive T-Lymphocytes-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung*-
dc.subject.MESHChemoradiotherapy / methods-
dc.subject.MESHHumans-
dc.subject.MESHImmune Checkpoint Inhibitors-
dc.subject.MESHLung Neoplasms*-
dc.subject.MESHLymphocytes, Tumor-Infiltrating-
dc.subject.MESHProgrammed Cell Death 1 Receptor-
dc.titleDynamics of Circulating Immune Cells During Chemoradiotherapy in Patients with Non-Small Cell Lung Cancer Support Earlier Administration of Anti-PD-1/PD-L1 Therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorHongryull Pyo-
dc.contributor.googleauthorHoyoung Lee-
dc.contributor.googleauthorDongryul Oh-
dc.contributor.googleauthorJae Myoung Noh-
dc.contributor.googleauthorYong Chan Ahn-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorHyowon Moon-
dc.contributor.googleauthorJiyun Lee-
dc.contributor.googleauthorSehhoon Park-
dc.contributor.googleauthorHyun-Ae Jung-
dc.contributor.googleauthorJong-Mu Sun-
dc.contributor.googleauthorSe-Hoon Lee-
dc.contributor.googleauthorJin Seok Ahn-
dc.contributor.googleauthorKeunchil Park-
dc.contributor.googleauthorBo Mi Ku-
dc.contributor.googleauthorMyung-Ju Ahn-
dc.contributor.googleauthorEui-Cheol Shin-
dc.identifier.doi10.1016/j.ijrobp.2022.02.003-
dc.contributor.localIdA04777-
dc.contributor.localIdA05226-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.pmid35150786-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0360301622001432?via%3Dihub-
dc.contributor.alternativeNameYoon, Hong In-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor김경환-
dc.citation.volume113-
dc.citation.number2-
dc.citation.startPage415-
dc.citation.endPage425-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.113(2) : 415-425, 2022-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.