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Risk of Anorectal Cancer Associated with Benign Anal Inflammatory Diseases: A Retrospective Matched Cohort Study

DC Field Value Language
dc.contributor.author장성인-
dc.contributor.author한윤대-
dc.contributor.author채원정-
dc.date.accessioned2022-12-22T02:23:35Z-
dc.date.available2022-12-22T02:23:35Z-
dc.date.issued2022-06-
dc.identifier.issn1661-7827-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191561-
dc.description.abstractPurpose: The purpose of our study was to evaluate the relationship between benign anal inflammatory diseases and anorectal cancer and assess its risk factors. Methods: A retrospective matched cohort study was conducted that included data from 2002 to 2013. The National Health Insurance Service National Sample Cohort data from 2002 to 2013 was used for the study. Of a total study population of 143,884 individuals, 28,110 individuals with anal fissures were assigned to the case group, while 115,774 individuals without anal fissures were assigned to the control group based on the 1:4 propensity score matching age, sex, and year (case: diagnosed year, control: health service received year). Results: The risk of anorectal cancer was higher in the case group (hazard ratio [HR]: 1.95, 95% confidence interval [CI]: 1.51-2.53) compared to the control group. After grouping anorectal cancers into anal cancer and rectal cancer, the risk remained higher in the case group (anal cancer HR: 2.79, 95% CI: 1.48-5.27; rectal cancer HR: 1.82, 95% CI; 1.37-2.42). The case group was further categorized into patients with fissures and patients with fistulas; patients with fissures showed a higher risk of developing anorectal cancer than patients with fistulas (HR: 2.05, 95% CI: 1.53-2.73 vs. HR: 1.73, 95% CI: 1.13-2.66). Study participants in their 30s and 40s had a 4.19- and 7.39-times higher risk of anorectal cancer compared to those in the higher age groups (0.64-1.84), while patients who did not have inflammatory bowel disease (IBD) had a higher risk of developing anorectal cancer (HR: 2.09, 95% CI: 1.56-2.80). Conclusions and relevance: Patients with anal fistulas or fissures have an increased risk of being diagnosed with anorectal cancer, especially at a young age and even without IBD.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnus Diseases* / complications-
dc.subject.MESHAnus Diseases* / diagnosis-
dc.subject.MESHAnus Diseases* / epidemiology-
dc.subject.MESHAnus Neoplasms* / epidemiology-
dc.subject.MESHCohort Studies-
dc.subject.MESHGastrointestinal Neoplasms* / complications-
dc.subject.MESHHumans-
dc.subject.MESHInflammatory Bowel Diseases* / complications-
dc.subject.MESHInflammatory Bowel Diseases* / epidemiology-
dc.subject.MESHRectal Neoplasms* / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.titleRisk of Anorectal Cancer Associated with Benign Anal Inflammatory Diseases: A Retrospective Matched Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학교실)-
dc.contributor.googleauthorWonjeong Chae-
dc.contributor.googleauthorSeung Yeon Kang-
dc.contributor.googleauthorSung-In Jang-
dc.contributor.googleauthorYoon Dae Han-
dc.identifier.doi10.3390/ijerph19127467-
dc.contributor.localIdA03439-
dc.contributor.localIdA04313-
dc.relation.journalcodeJ01111-
dc.identifier.eissn1660-4601-
dc.identifier.pmid35742716-
dc.subject.keywordanal fissure-
dc.subject.keywordanal fistula-
dc.subject.keywordanorectal cancer-
dc.subject.keywordbenign anal inflammatory diseases-
dc.contributor.alternativeNameJang, Sung In-
dc.contributor.affiliatedAuthor장성인-
dc.contributor.affiliatedAuthor한윤대-
dc.citation.volume19-
dc.citation.number12-
dc.citation.startPage7467-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol.19(12) : 7467, 2022-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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