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Immunoinflammatory and vascular inflammatory factors can be potential disease biomarkers of age-related hearing loss
DC Field | Value | Language |
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dc.contributor.author | 문인석 | - |
dc.contributor.author | 한지혁 | - |
dc.date.accessioned | 2022-12-22T02:22:02Z | - |
dc.date.available | 2022-12-22T02:22:02Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 1721-727X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191547 | - |
dc.description.abstract | Objectives: The relationship between age-related diseases and chronic inflammation associated with aging has recently been investigated. This study aimed to investigate how chronic inflammation is associated with age-related hearing loss (ARHL). Methods: Twenty ARHL patients aged ≥65 years were prospectively enrolled from July 1 to 31 December 2015. Audiological tests and serological tests, such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), immunoglobulin G (IgG), interleukin 6 (IL-6), white blood cell (WBC) counts, neutrophil counts, lymphocyte counts, and platelet counts, were performed. The patients were divided into two groups: mild hearing loss group (n = 7) and moderate to profound hearing loss group (n = 13). Results: Immunoinflammatory biomarkers, such as CRP, ESR, and IL-6, and vascular inflammatory biomarkers, such as neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, were higher in the moderate to profound hearing loss group. IgG, WBC counts, and neutrophil counts were similar in both groups. Conclusion: The present preliminary pilot study demonstrated that high levels of inflammatory biomarkers may be associated with ARHL. The results suggest a possible association between chronic inflammation and ARHL. Further well-designed studies of ARHL, based on a new perspective of chronic inflammation, should be performed. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Sage Publications | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF INFLAMMATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Immunoinflammatory and vascular inflammatory factors can be potential disease biomarkers of age-related hearing loss | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Junhui Jeong | - |
dc.contributor.googleauthor | Ji Hyuk Han | - |
dc.contributor.googleauthor | Hyun Seung Choi | - |
dc.contributor.googleauthor | In Seok Moon | - |
dc.identifier.doi | 10.1177/1721727X221110078 | - |
dc.contributor.localId | A01374 | - |
dc.contributor.localId | A04812 | - |
dc.relation.journalcode | J04346 | - |
dc.identifier.eissn | * | - |
dc.subject.keyword | Presbycusis | - |
dc.subject.keyword | age-related hearing loss | - |
dc.subject.keyword | chronic inflammation | - |
dc.subject.keyword | immunity | - |
dc.subject.keyword | biomarker | - |
dc.contributor.alternativeName | Moon, In Seok | - |
dc.contributor.affiliatedAuthor | 문인석 | - |
dc.contributor.affiliatedAuthor | 한지혁 | - |
dc.citation.volume | 20 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF INFLAMMATION, Vol.20 : 1-5, 2022-06 | - |
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