Cited 14 times in
Platelet Function and Genotype after DES Implantation in East Asian Patients: Rationale and Characteristics of the PTRG-DES Consortium
DC Field | Value | Language |
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dc.contributor.author | 김병극 | - |
dc.date.accessioned | 2022-12-22T02:08:29Z | - |
dc.date.available | 2022-12-22T02:08:29Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191469 | - |
dc.description.abstract | Purpose: Platelet function test (PFT) results and genotype hold unique prognostic implications in East Asian patients. The aim of the PTRG-DES (Platelet function and genoType-Related long-term proGnosis in Drug-Eluting Stent-treated Patients with coronary artery disease) consortium is to assess the clinical impact thereof on long-term clinical outcomes in Korean patients with coronary artery disease during dual antiplatelet therapy (DAPT) including clopidogrel. Materials and methods: Searching publications on the PubMed, we reviewed clopidogrel treatment studies with PFT and/or genotype data for potential inclusion in this study. Lead investigators were invited to share PFT/genotype results, patient characteristics, and clinical outcomes to evaluate relationships among them. Results: Nine registries from 32 academic centers participated in the PTRG-DES consortium, contributing individual patient data from 13160 patients who underwent DES implantation between July 2003 and August 2018. The PTRG-PFT cohort was composed of 11714 patients with available VerifyNow assay results. Platelet reactivity levels reached 218±79 P2Y12 reaction units (PRU), and high on-clopidogrel platelet reactivity based on a consensus-recommended cutoff (PRU >208) was observed in 55.9%. The PTRG-Genotype cohort consisted of 8163 patients with candidate genotypes related with clopidogrel responsiveness. Of those with cytochrome P450 (CYP) 2C19 genotype, frequencies of carrying one and two loss-of-function allele (s) (*2 or *3) were 47.9% (intermediate metabolizers) and 14.2% (poor metabolizers), respectively. Conclusion: The PTRG-DES consortium highlights unique values for on-clopidogrel platelet reactivity and CYP2C19 phenotype that may be important to developing optimal antiplatelet regimens in East Asian patients. Trial registration: ClinicalTrials.gov Identifier: NCT04734028. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Clinical Studies as Topic | - |
dc.subject.MESH | Clopidogrel / therapeutic use | - |
dc.subject.MESH | Coronary Artery Disease* / drug therapy | - |
dc.subject.MESH | Coronary Artery Disease* / genetics | - |
dc.subject.MESH | Coronary Artery Disease* / surgery | - |
dc.subject.MESH | Cytochrome P-450 CYP2C19 / genetics | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Platelet Function Tests | - |
dc.title | Platelet Function and Genotype after DES Implantation in East Asian Patients: Rationale and Characteristics of the PTRG-DES Consortium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ae-Young Her | - |
dc.contributor.googleauthor | Young-Hoon Jeong | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Hyung Joon Joo | - |
dc.contributor.googleauthor | Kiyuk Chang | - |
dc.contributor.googleauthor | Yongwhi Park | - |
dc.contributor.googleauthor | Young Bin Song | - |
dc.contributor.googleauthor | Sung Gyun Ahn | - |
dc.contributor.googleauthor | Jung-Won Suh | - |
dc.contributor.googleauthor | Sang Yeup Lee | - |
dc.contributor.googleauthor | Jung Rae Cho | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Moo Hyun Kim | - |
dc.contributor.googleauthor | Do-Sun Lim | - |
dc.contributor.googleauthor | Eun-Seok Shin | - |
dc.identifier.doi | 10.3349/ymj.2022.63.5.413 | - |
dc.contributor.localId | A00493 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 35512743 | - |
dc.subject.keyword | East Asia | - |
dc.subject.keyword | coronary artery disease | - |
dc.subject.keyword | drug-eluting stent | - |
dc.subject.keyword | genotype | - |
dc.subject.keyword | platelet function | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | 김병극 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 413 | - |
dc.citation.endPage | 421 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.63(5) : 413-421, 2022-05 | - |
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