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Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 양재석 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2022-12-22T02:08:22Z | - |
dc.date.available | 2022-12-22T02:08:22Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0934-0874 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191468 | - |
dc.description.abstract | The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo, or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol (p < 0.001) and low-density lipoprotein cholesterol levels (p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels (p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Blackwell Pub. | - |
dc.relation.isPartOf | TRANSPLANT INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alcohol Drinking / adverse effects | - |
dc.subject.MESH | Cardiovascular Diseases* | - |
dc.subject.MESH | Cholesterol | - |
dc.subject.MESH | Graft Rejection | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation* / adverse effects | - |
dc.subject.MESH | Lipids | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hee-Yeon Jung | - |
dc.contributor.googleauthor | Yena Jeon | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Jae Berm Park | - |
dc.contributor.googleauthor | Myung-Gyu Kim | - |
dc.contributor.googleauthor | Sik Lee | - |
dc.contributor.googleauthor | Seungyeup Han | - |
dc.contributor.googleauthor | Han Ro | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.contributor.googleauthor | Curie Ahn | - |
dc.contributor.googleauthor | Jang-Hee Cho | - |
dc.contributor.googleauthor | Sun-Hee Park | - |
dc.contributor.googleauthor | Yong-Lim Kim | - |
dc.contributor.googleauthor | Chan-Duck Kim | - |
dc.identifier.doi | 10.3389/ti.2022.10243 | - |
dc.contributor.localId | A06130 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J02753 | - |
dc.identifier.eissn | 1432-2277 | - |
dc.identifier.pmid | 35707634 | - |
dc.subject.keyword | alcohol | - |
dc.subject.keyword | all-cause mortality | - |
dc.subject.keyword | biopsy-proven acute rejection | - |
dc.subject.keyword | cardiovascular events | - |
dc.subject.keyword | death-censored graft failure | - |
dc.subject.keyword | kidney transplantation | - |
dc.subject.keyword | low-density lipoprotein cholesterol | - |
dc.subject.keyword | total cholesterol | - |
dc.contributor.alternativeName | Yang, Jaeseok | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 35 | - |
dc.citation.startPage | 10243 | - |
dc.identifier.bibliographicCitation | TRANSPLANT INTERNATIONAL, Vol.35 : 10243, 2022-05 | - |
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