A prospective multi-centre study of susceptibility map-weighted MRI for the diagnosis of neurodegenerative parkinsonism
Authors
Young Hee Sung ; Joong-Seok Kim ; Sang-Won Yoo ; Na-Young Shin ; Yoonho Nam ; Tae-Beom Ahn ; Dallah Yoo ; Kyung Mi Lee ; Hyug-Gi Kim ; Seong-Beom Koh ; Jinhee Kim ; Ilsoo Kim ; Do-Young Kwon ; Younghen Lee ; Chulhan Kim ; Sun Ju Chung ; Sungyang Jo ; Seung Hyun Lee ; Sang Joon Kim ; Minjae Kim ; Chul Hyoung Lyoo ; Min Seok Baek ; Suk Yun Kang ; Suk Ki Chang ; Sang-Won Jo ; Seun Ah Lee ; Hyeo-Il Ma ; Young Eun Kim ; Eun Soo Kim ; Yun Joong Kim ; Hyun Sook Kim ; Min-Hee Woo ; Hye Jeong Choi ; Eung Yeop Kim
Citation
EUROPEAN RADIOLOGY, Vol.32(5) : 3597-3608, 2022-05
Magnetic resonance imaging ; Parkinson disease ; Substantia nigra
Abstract
Objectives This study aimed to compare susceptibility map-weighted imaging (SMwI) using various MRI machines (three vendors) with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophe nyl)nortropane (F-18-FP-CIT) PET in the Objectives: This study aimed to compare susceptibility map-weighted imaging (SMwI) using various MRI machines (three vendors) with N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophe nyl)nortropane (18F-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism in a multi-centre setting.
Methods: We prospectively recruited 257 subjects, including 157 patients with neurodegenerative parkinsonism, 54 patients with non-neurodegenerative parkinsonism, and 46 healthy subjects from 10 hospitals between November 2019 and October 2020. All participants underwent both SMwI and 18F-FP-CIT PET. SMwI was interpreted by two independent reviewers for the presence or absence of abnormalities in nigrosome 1, and discrepancies were resolved by consensus. 18F-FP-CIT PET was used as the reference standard. Inter-observer agreement was tested using Cohen's kappa coefficient. McNemar's test was used to test the agreement between the interpretations of SMwI and 18F-FP-CIT PET per participant and substantia nigra (SN).
Results: The inter-observer agreement was 0.924 and 0.942 per SN and participant, respectively. The diagnostic sensitivity of SMwI was 97.9% and 99.4% per SN and participant, respectively; its specificity was 95.9% and 95.2%, respectively, and its accuracy was 97.1% and 97.7%, respectively. There was no significant difference between the results of SMwI and 18F-FP-CIT PET (p > 0.05, for both SN and participant).
Conclusions: This study demonstrated that the high diagnostic performance of SMwI was maintained in a multi-centre setting with various MRI scanners, suggesting the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism.
Key points: • Susceptibility map-weighted imaging helps clinicians to predict nigrostriatal degeneration. • The protocol for susceptibility map-weighted imaging can be standardised across MRI vendors. • Susceptibility map-weighted imaging showed diagnostic performance comparable to that of dopamine transporter PET in a multi-centre setting with various MRI scanners.