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High Circulating Levels of Neutrophil Extracellular Traps Parameters Predicting Poor Outcome in COVID-19
DC Field | Value | Language |
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dc.contributor.author | 홍기호 | - |
dc.contributor.author | 김희주 | - |
dc.date.accessioned | 2022-12-22T01:58:21Z | - |
dc.date.available | 2022-12-22T01:58:21Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0091-7370 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191405 | - |
dc.description.abstract | Objective: Exploration of biomarkers to predict the severity of COVID-19 is important to reduce mortality. Upon COVID-19 infection, neutrophil extracellular traps (NET) are formed, which leads to a cytokine storm and host damage. Hence, the extent of NET formation may reflect disease progression and predict mortality in COVID-19. Methods: We measured 4 NET parameters - cell-free double stranded DNA (cell-free dsDNA), neutrophil elastase, citrullinated histone H3 (Cit-H3), and histone - DNA complex - in 188 COVID-19 patients and 20 healthy controls. Survivors (n=166) were hospitalized with or without oxygen supplementation, while non-survivors (n=22) expired during in-hospital treatment. Results: Cell-free dsDNA was significantly elevated in non-survivors in comparison with survivors and controls. The survival rate of patients with high levels of cell-free dsDNA, neutrophil elastase, and Cit-H3 was significantly lower than that of patients with low levels. These three markers significantly correlated with inflammatory markers (absolute neutrophil count and C-reactive protein). Conclusion: Since the increase in NET parameters indicates the unfavourable course of COVID-19 infection, patients predisposed to poor outcome can be rapidly managed through risk stratification by using these NET parameters. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Institute for Clinical Science | - |
dc.relation.isPartOf | ANNALS OF CLINICAL AND LABORATORY SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers / metabolism | - |
dc.subject.MESH | COVID-19* / diagnosis | - |
dc.subject.MESH | Cell-Free Nucleic Acids / blood | - |
dc.subject.MESH | Cell-Free Nucleic Acids / metabolism | - |
dc.subject.MESH | Extracellular Traps* / metabolism | - |
dc.subject.MESH | Histones / blood | - |
dc.subject.MESH | Histones / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukocyte Elastase / blood | - |
dc.subject.MESH | Leukocyte Elastase / metabolism | - |
dc.subject.MESH | Neutrophils / metabolism | - |
dc.subject.MESH | Prognosis | - |
dc.title | High Circulating Levels of Neutrophil Extracellular Traps Parameters Predicting Poor Outcome in COVID-19 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Seunghwan Kim | - |
dc.contributor.googleauthor | Ki Ho Hong | - |
dc.contributor.googleauthor | Ja-Yoon Gu | - |
dc.contributor.googleauthor | Ji Won In | - |
dc.contributor.googleauthor | Mi Young Ahn | - |
dc.contributor.googleauthor | Hyun Kyung Kim | - |
dc.contributor.localId | A06207 | - |
dc.relation.journalcode | J00155 | - |
dc.identifier.eissn | 1550-8080 | - |
dc.identifier.pmid | 35777794 | - |
dc.identifier.url | http://www.annclinlabsci.org/content/52/3/374.long | - |
dc.subject.keyword | Cell-free DNA | - |
dc.subject.keyword | Citrullinated histone H3 | - |
dc.subject.keyword | Histone-DNA complex | - |
dc.subject.keyword | Neutrophil elastase | - |
dc.subject.keyword | Neutrophil extracellular trap | - |
dc.contributor.alternativeName | Hong, Ki Ho | - |
dc.contributor.affiliatedAuthor | 홍기호 | - |
dc.citation.volume | 52 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 374 | - |
dc.citation.endPage | 381 | - |
dc.identifier.bibliographicCitation | ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol.52(3) : 374-381, 2022-05 | - |
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