Cited 23 times in
Age and Outcomes of Early Rhythm Control in Patients With Atrial Fibrillation: Nationwide Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유희태 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 유승찬 | - |
dc.contributor.author | 김대훈 | - |
dc.contributor.author | 김태훈 | - |
dc.contributor.author | 박희남 | - |
dc.date.accessioned | 2022-12-22T01:55:15Z | - |
dc.date.available | 2022-12-22T01:55:15Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2405-500X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191387 | - |
dc.description.abstract | Objectives: This study sought to investigate whether the effects of early rhythm control differ according to age. Background: Rhythm control, compared with usual care among patients recently diagnosed with atrial fibrillation (AF), was found to be associated with a lower risk of adverse cardiovascular outcomes. It is unclear whether the results can be generalized for older adults. Methods: This retrospective population-based cohort study included 31,220 patients with AF, from the Korean National Health Insurance Service database, undergoing rhythm control (antiarrhythmic drugs or ablation) or rate control therapy, initiated within 1 year of AF diagnosis. A composite outcome of cardiovascular death, ischemic stroke, hospitalization for heart failure, or myocardial infarction was compared in subgroups stratified by age. Results: Compared with rate control, early rhythm control was associated with a lower risk of the primary composite outcome in patients <75 years of age (HR: 0.80; 95% CI: 0.72-0.88). The protective association between early rhythm control and cardiovascular outcomes exhibited a linear decrease with advancing age, with declined benefits in patients ≥75 years of age (HR: 0.94; 95% CI: 0.87-1.03; Pinteraction = 0.045). Trends toward lower risks of ischemic stroke (HR: 0.78; 95% CI: 0.67-0.90) and acute myocardial infarction (HR: 0.63; 95% CI: 0.41-0.97) were observed in the older adults. No significant differences in safety outcomes were found across different ages. Conclusions: The beneficial association of early rhythm control with cardiovascular outcomes was attenuated with increasing age, with the larger benefits in younger patients <75 years of age. No differences were found by age in treatment-related safety outcomes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isPartOf | JACC. Clinical Electrophysiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Arrhythmia Agents / therapeutic use | - |
dc.subject.MESH | Atrial Fibrillation* / complications | - |
dc.subject.MESH | Atrial Fibrillation* / drug therapy | - |
dc.subject.MESH | Atrial Fibrillation* / epidemiology | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ischemic Stroke* | - |
dc.subject.MESH | Myocardial Infarction* / complications | - |
dc.subject.MESH | Myocardial Infarction* / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Age and Outcomes of Early Rhythm Control in Patients With Atrial Fibrillation: Nationwide Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Daehoon Kim | - |
dc.contributor.googleauthor | Pil-Sung Yang | - |
dc.contributor.googleauthor | Seng Chan You | - |
dc.contributor.googleauthor | Eunsun Jang | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Gregory Y H Lip | - |
dc.contributor.googleauthor | Jung-Hoon Sung | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.1016/j.jacep.2022.02.014 | - |
dc.contributor.localId | A02535 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A02478 | - |
dc.contributor.localId | A00373 | - |
dc.contributor.localId | A01085 | - |
dc.contributor.localId | A01776 | - |
dc.relation.journalcode | J03493 | - |
dc.identifier.eissn | 2405-5018 | - |
dc.identifier.pmid | 35589174 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2405500X22002213?via%3Dihub | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | cardiovascular outcome | - |
dc.subject.keyword | rate control | - |
dc.subject.keyword | rhythm control | - |
dc.contributor.alternativeName | Yu, Hee Tae | - |
dc.contributor.affiliatedAuthor | 유희태 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.contributor.affiliatedAuthor | 이문형 | - |
dc.contributor.affiliatedAuthor | 유승찬 | - |
dc.contributor.affiliatedAuthor | 김대훈 | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.contributor.affiliatedAuthor | 박희남 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 619 | - |
dc.citation.endPage | 632 | - |
dc.identifier.bibliographicCitation | JACC. Clinical Electrophysiology, Vol.8(5) : 619-632, 2022-05 | - |
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