Cited 2 times in
Vitamin D Receptor Expression and its Clinical Significance in Papillary Thyroid Cancer
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김다함 | - |
dc.contributor.author | 남기현 | - |
dc.contributor.author | 이주희 | - |
dc.contributor.author | 김민지 | - |
dc.date.accessioned | 2022-12-22T01:52:44Z | - |
dc.date.available | 2022-12-22T01:52:44Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1533-0346 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191372 | - |
dc.description.abstract | Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Methods: This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Results: Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. Conclusions: An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | SAGE | - |
dc.relation.isPartOf | TECHNOLOGY IN CANCER RESEARCH & TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Receptors, Calcitriol* / genetics | - |
dc.subject.MESH | Thyroid Cancer, Papillary / genetics | - |
dc.subject.MESH | Thyroid Neoplasms* / pathology | - |
dc.title | Vitamin D Receptor Expression and its Clinical Significance in Papillary Thyroid Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Min Jhi Kim | - |
dc.contributor.googleauthor | Daham Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.identifier.doi | 10.1177/15330338221089933 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A00363 | - |
dc.contributor.localId | A01245 | - |
dc.contributor.localId | A03171 | - |
dc.relation.journalcode | J02714 | - |
dc.identifier.eissn | 1533-0338 | - |
dc.identifier.pmid | 35379049 | - |
dc.subject.keyword | papillary thyroid cancer | - |
dc.subject.keyword | surgery | - |
dc.subject.keyword | vitamin D | - |
dc.subject.keyword | vitamin D receptor | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 김다함 | - |
dc.contributor.affiliatedAuthor | 남기현 | - |
dc.contributor.affiliatedAuthor | 이주희 | - |
dc.citation.volume | 21 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.identifier.bibliographicCitation | TECHNOLOGY IN CANCER RESEARCH & TREATMENT, Vol.21 : 1-12, 2022-04 | - |
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