Cited 6 times in
Prognostic impact of neutrophilia and lymphopenia on survival in anal cancer treated with definitive concurrent chemoradiotherapy: a retrospective multicenter study
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김경환 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 김태형 | - |
dc.date.accessioned | 2022-12-22T01:39:48Z | - |
dc.date.available | 2022-12-22T01:39:48Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1341-9625 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191288 | - |
dc.description.abstract | Purpose: This study evaluated the prognostic value of leukocyte, lymphocyte, and neutrophil counts in anal cancer patients undergoing concurrent chemoradiotherapy (CCRT). Methods: Multi-institutional retrospective data review included 148 non-metastatic anal cancer patients treated with definitive CCRT with 5-fluorouracil plus mitomycin C between the year 2001 and 2019. The median radiation dose to the primary tumor was 54 Gy with a median pelvic dose of 45 Gy. Median follow-up duration was 56 months, and complete blood cell counts were analyzed from baseline to 1 year after the completion of radiotherapy. Results: Although most patients showed a normal number of blood cells before treatment, 6.1% and 4.1% of patients showed leukocytosis (> 10,000/μl) and neutrophilia (> 7500/μl), respectively. After the initiation of treatment, seven patients (4.7%) displayed grade 4 lymphopenia (< 200/μl) at 1 month. Patients with initial leukocytosis showed inferior progression- and locoregional progression-free survival, and neutrophilia was a prognostic factor in all survival outcomes. Grade 4 lymphopenia at 1 month was also significantly associated with overall, progression-, and distant metastasis-free survival. On multivariate analyses, baseline neutrophilia was associated with 56.8-, 22.6-, 10.7-, and 23.0-fold increased risks of death, disease relapse, locoregional progression, and distant metastasis, respectively. Furthermore, lymphocytes < 200/μl at 1 month was linked to 6.8-, 5.4-, and 6.3-fold increased risks for death, disease relapse, and distant metastasis, respectively. Conclusion: The number of leukocytes, lymphocytes, and neutrophils readily acquired from routine blood tests before and during treatment could be an independent prognostic factor of survival in patients with anal cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag Tokyo | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anus Neoplasms* / drug therapy | - |
dc.subject.MESH | Carcinoma, Squamous Cell* / pathology | - |
dc.subject.MESH | Chemoradiotherapy / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukocytosis / drug therapy | - |
dc.subject.MESH | Leukocytosis / etiology | - |
dc.subject.MESH | Lymphopenia* / etiology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Prognostic impact of neutrophilia and lymphopenia on survival in anal cancer treated with definitive concurrent chemoradiotherapy: a retrospective multicenter study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Eunji Kim | - |
dc.contributor.googleauthor | Tae Hyung Kim | - |
dc.contributor.googleauthor | Wonguen Jung | - |
dc.contributor.googleauthor | Kyubo Kim | - |
dc.contributor.googleauthor | Ah Ram Chang | - |
dc.contributor.googleauthor | Hae Jin Park | - |
dc.contributor.googleauthor | Hyeon Kang Koh | - |
dc.contributor.googleauthor | Semie Hong | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Won Il Jang | - |
dc.contributor.googleauthor | Mi-Sook Kim | - |
dc.identifier.doi | 10.1007/s10147-021-02094-5 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A05226 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J01097 | - |
dc.identifier.eissn | 1437-7772 | - |
dc.identifier.pmid | 34842994 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10147-021-02094-5 | - |
dc.subject.keyword | Anal squamous cell carcinoma | - |
dc.subject.keyword | Chemoradiotherapy | - |
dc.subject.keyword | Lymphopenia | - |
dc.subject.keyword | Neutrophilia | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | 금웅섭 | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.contributor.affiliatedAuthor | 장지석 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 553 | - |
dc.citation.endPage | 562 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Vol.27(3) : 553-562, 2022-03 | - |
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