Cited 5 times in
Insular activation and functional connectivity in firefighters with post-traumatic stress disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창수 | - |
dc.contributor.author | 이덕종 | - |
dc.contributor.author | 이정한 | - |
dc.contributor.author | 정영철 | - |
dc.date.accessioned | 2022-12-22T01:38:30Z | - |
dc.date.available | 2022-12-22T01:38:30Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | * | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191277 | - |
dc.description.abstract | Background: Firefighters are frequently exposed to stressful situations and are at high risk of developing post-traumatic stress disorder (PTSD). Hyperresponsiveness to threatening and emotional stimuli and diminishment of executive control have been suggested as manifestations of PTSD. Aims: To examine brain activation in firefighters with PTSD by conducting an executive control-related behavioural task with trauma-related interferences. Method: Twelve firefighters with PTSD and 14 healthy firefighters underwent functional magnetic resonance imaging (fMRI) while performing a Stroop match-to-sample task using trauma-related photographic stimuli. Seed-based functional connectivity analysis was conducted using regions identified in fMRI contrast analysis. Results: Compared with the controls, the participants with PTSD had longer reaction times when the trauma-related interferences were presented. They showed significantly stronger brain activation to interfering trauma-related stimuli in the left insula, and had weaker insular functional connectivity in the supplementary motor area and the anterior cingulate cortex than the controls. They also showed a significant correlation between left insula-supplementary motor area connectivity strength and the hyperarousal subscale of the Clinician-Administered PTSD Scale. Conclusions: Our findings indicate that trauma-related stimuli elicit excessive brain activation in the left insula among firefighters with PTSD. Firefighters with PTSD also appear to have weak left insular functional connectivity with executive control-related brain regions. This aberrant insular activation and functional connectivity could be related to the development and maintenance of PTSD symptoms in firefighters. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cambridge University Press | - |
dc.relation.isPartOf | BJPSYCH OPEN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Insular activation and functional connectivity in firefighters with post-traumatic stress disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Deokjong Lee | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.contributor.googleauthor | Junghan Lee | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Young-Chul Jung | - |
dc.identifier.doi | 10.1192/bjo.2022.32 | - |
dc.contributor.localId | A01042 | - |
dc.contributor.localId | A04869 | - |
dc.contributor.localId | A05799 | - |
dc.contributor.localId | A03656 | - |
dc.relation.journalcode | J04335 | - |
dc.identifier.eissn | 2056-4724 | - |
dc.identifier.pmid | 35287782 | - |
dc.subject.keyword | Post-traumatic stress disorder | - |
dc.subject.keyword | firefighters | - |
dc.subject.keyword | functional MRI | - |
dc.subject.keyword | insula | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | 김창수 | - |
dc.contributor.affiliatedAuthor | 이덕종 | - |
dc.contributor.affiliatedAuthor | 이정한 | - |
dc.contributor.affiliatedAuthor | 정영철 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e69 | - |
dc.identifier.bibliographicCitation | BJPSYCH OPEN, Vol.8(2) : e69, 2022-03 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.