Cited 9 times in
CRT Efficacy in "Mid-Range" QRS Duration Among Asians Contrasted to Non-Asians, and Influence of Height
DC Field | Value | Language |
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dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2022-12-22T01:25:48Z | - |
dc.date.available | 2022-12-22T01:25:48Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 2405-500X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191214 | - |
dc.description.abstract | Objectives: The purpose of this study was to test the hypotheses that cardiac resynchronization therapy (CRT) efficacy differed among Asians compared with non-Asian populations, differed between QRS duration (QRSd) ranges 120-149 and ≥150 ms, and was influenced by height in the multinational ADVANCE CRT trial. Background: CRT guidelines, derived from trials among U.S./European patients, assign weaker recommendations to those with midrange QRSd (QRSd <150 ms). Patient height may modulate CRT efficacy. Together, these may affect CRT prescription and efficacy in Asia. Methods: CRT response was assessed using the Clinical Composite Score 6 months postimplant (n = 934). Heart failure events and cardiac deaths were reported until 12 months. Asian and non-Asian patients were compared overall, by QRSd <150 ms (Asian n = 71 vs non-Asian n = 248), and QRSd ≥150 ms (Asian n = 180 vs non-Asian n = 435) and by height. Results: Asians comprised 27% (251 of 934) of the primary study population. More Asians had QRSd ≥150 ms (72% [180 of 251] vs 64% [435 of 683] in non-Asian patients; P = 0.022). Overall CRT response was better in Asians vs non-Asians (Clinical Composite Score 85% vs 65%; P <0.001), and following QRSd dichotomization (QRSd <150 ms: 80% vs 59%; P <0.001; QRS ≥150 ms: 86% vs 69%; P < 0.001). HF events and cardiac deaths were fewer in Asians irrespective of QRSd (P < 0.001). Stepwise multivariable analysis indicated that in group QRSd <150 ms, nonischemic cardiomyopathy, number of other comorbidities (0-1 vs ≥4), and atrial fibrillation influenced CRT response. The trend favoring Asian race (OR: 1.46; 95% CI: 0.72-2.95) was eliminated (OR: 1.00; 95% CI: 0.47-2.11) when height or QRSd/height were included (QRSd/height P = 0.006; OR: 1.64; 95% CI: 1.15-2.35). In QRSd <150 ms, probability of CRT response diminished as height increased, but increased with QRSd/height, in both Asians and non-Asians. In QRSd ≥150 ms, height or QRSd/height had minimal effect in Asians or non-Asians. Conclusions: Height modulates CRT efficacy among patients with QRSd <150 ms and contributes to high probability of benefit from CRT among Asians. CRT should be encouraged among Asian patients with midrange QRSd. (Advance Cardiac Resynchronization Therapy [CRT] Registry; NCT01805154). | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isPartOf | JACC. Clinical Electrophysiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Asians | - |
dc.subject.MESH | Cardiac Resynchronization Therapy* | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Heart Failure* / therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | CRT Efficacy in "Mid-Range" QRS Duration Among Asians Contrasted to Non-Asians, and Influence of Height | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Niraj Varma | - |
dc.contributor.googleauthor | Jian-An Wang | - |
dc.contributor.googleauthor | Aparna Jaswal | - |
dc.contributor.googleauthor | Kamal K Sethi | - |
dc.contributor.googleauthor | Yusuke Kondo | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Dale Yoo | - |
dc.contributor.googleauthor | Angelo Auricchio | - |
dc.contributor.googleauthor | Jagmeet P Singh | - |
dc.contributor.googleauthor | Kwangdeok Lee | - |
dc.contributor.googleauthor | Michael R Gold | - |
dc.identifier.doi | 10.1016/j.jacep.2021.09.012 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J03493 | - |
dc.identifier.eissn | 2405-5018 | - |
dc.identifier.pmid | 34838518 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2405500X21008562?via%3Dihub | - |
dc.subject.keyword | Asian | - |
dc.subject.keyword | CRT | - |
dc.subject.keyword | QRS duration | - |
dc.subject.keyword | height | - |
dc.subject.keyword | race | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 221 | - |
dc.identifier.bibliographicCitation | JACC. Clinical Electrophysiology, Vol.8(2) : 211-221, 2022-02 | - |
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