Cited 3 times in
Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops
DC Field | Value | Language |
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dc.date.accessioned | 2022-11-24T01:00:11Z | - |
dc.date.available | 2022-11-24T01:00:11Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1976-8710 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191122 | - |
dc.description.abstract | Objectives: The aims of this study were to investigate the effects of intratympanic injections of isosorbide on vestibular function in animal models of endolymphatic hydrops and to find a new treatment option for the acute onset of vertigo in Ménière disease (MD). Methods: Seventy male guinea pigs received intratympanic injection of isosorbide (IT-ISB). The animals were divided into three study groups: control, a chronic hydrops model, and an acute hydrops model. Intracochlear drug concentrations were measured using high-performance liquid chromatography. Vestibular function was analyzed using an animal rotator test with bidirectional sinusoidal harmonic acceleration before and after IT-ISB administration. Histological changes were also investigated. Results: ISB successfully permeated the perilymph through the round window membrane (RWM) at all three concentrations (25%, 50%, and 100%). In the chronic hydrops model, while IT-ISB histologically induced a reduction of endolymphatic hydrops, vestibular function was unchanged. In the acute hydrops model, no endolymphatic hydrops was histologically observed, and vestibular symmetry was also preserved after IT-ISB. Conclusion: ISB passed through the RWM into the perilymphatic space even at lower concentrations. IT-ISB histologically reduced hydrops in the chronic model and preserved symmetrical vestibular function in the acute model. IT-ISB could be a treatment candidate for acute attacks of vertigo in MD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Otorhinolaryngology--Head and Neck Surgery | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Minbum Kim | - |
dc.contributor.googleauthor | So Yeon Yoon | - |
dc.contributor.googleauthor | Hansol Hong | - |
dc.contributor.googleauthor | Hyun Jun Hong | - |
dc.identifier.doi | 10.21053/ceo.2019.02040 | - |
dc.relation.journalcode | J00552 | - |
dc.identifier.eissn | 2005-0720 | - |
dc.identifier.pmid | 33092316 | - |
dc.subject.keyword | Isosorbide | - |
dc.subject.keyword | Ménière’s disease | - |
dc.subject.keyword | endolymphatic hydrops | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 367 | - |
dc.citation.endPage | 373 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, Vol.14(4) : 367-373, 2021-11 | - |
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