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The tacrolimus metabolism affect post-transplant outcome mediating acute rejection and delayed graft function: analysis from Korean Organ Transplantation Registry data
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.date.accessioned | 2022-11-24T00:55:37Z | - |
dc.date.available | 2022-11-24T00:55:37Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0934-0874 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191085 | - |
dc.description.abstract | Tacrolimus is a key drug in kidney transplantation (KT) with a narrow therapeutic index. The association between the tacrolimus metabolism rate and KT outcomes have not been investigated in large-scale multi-center studies. The Korean Organ Transplantation Registry (KOTRY) datasets were used. A total of 3456 KT recipients were analyzed. The tacrolimus metabolism rate was defined as blood trough concentration of tacrolimus (C0 ) divided by the daily dose (D). The patients were grouped into fast, intermediate, or slow metabolizers by the C0 /D measured 6 months after transplantation. The slow metabolism group was associated with a 2.7 ml/min/1.73 m2 higher adjusted estimated glomerular filtration rate (eGFR) at 6 months [95% confidence interval (C.I.) 1.2-4.3, P = 0.001], less acute rejection (AR) within 6 months [Odds ratio (OR) 0.744, 95% C.I. 0.585-0.947, P = 0.016], and less interstitial fibrosis and tubular atrophy [OR 0.606, 95% C.I. 0.390-0.940, P = 0.025]. Fast tacrolimus metabolism affected the 6-month post-KT eGFR through mediation of AR [natural indirect effect (NIE) -0.434, 95% C.I. -0.856 to -0.012, P = 0.044) and delayed graft function (DGF; NIE -0.119, 95% C.I. -0.231 to -0.007, P = 0.038). Slow tacrolimus metabolism was associated with better post-KT eGFR. AR and DGF were found to be significant mediators. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Pub. | - |
dc.relation.isPartOf | TRANSPLANT INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Delayed Graft Function | - |
dc.subject.MESH | Graft Rejection | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents | - |
dc.subject.MESH | Kidney Transplantation* / adverse effects | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Tacrolimus* | - |
dc.title | The tacrolimus metabolism affect post-transplant outcome mediating acute rejection and delayed graft function: analysis from Korean Organ Transplantation Registry data | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Han Ro | - |
dc.contributor.googleauthor | Jong Cheol Jeong | - |
dc.contributor.googleauthor | Jin Min Kong | - |
dc.contributor.googleauthor | Ji Won Min | - |
dc.contributor.googleauthor | Sung Kwang Park | - |
dc.contributor.googleauthor | Joongyub Lee | - |
dc.contributor.googleauthor | Tai Yeon Koo | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Seungsik Hwang | - |
dc.contributor.googleauthor | Curie Ahn | - |
dc.identifier.doi | 10.1111/tri.13777 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J02753 | - |
dc.identifier.eissn | 1432-2277 | - |
dc.identifier.pmid | 33098694 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/tri.13777 | - |
dc.subject.keyword | kidney transplantation | - |
dc.subject.keyword | pharmacogenetics | - |
dc.subject.keyword | tacrolimus metabolism | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 174 | - |
dc.identifier.bibliographicCitation | TRANSPLANT INTERNATIONAL, Vol.34(1) : 163-174, 2021-01 | - |
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