Cited 9 times in
Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 김지현 | - |
dc.date.accessioned | 2022-11-24T00:55:15Z | - |
dc.date.available | 2022-11-24T00:55:15Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191081 | - |
dc.description.abstract | Background: This study aimed to investigate risk factors for lymph node (LN) or distant metastasis after non-curative endoscopic resection (ER) of undifferentiated-type early gastric cancer (EGC). Methods: Of 1124 patients who underwent ER for undifferentiated-type gastric cancer at 18 tertiary hospitals across six geographic areas in Korea between 2005 and 2014, 634 with non-curative ER beyond the expanded criteria were retrospectively enrolled. According to the treatment after ER, patients were divided into additional surgery (n = 270) and follow-up (n = 364) groups. The median follow-up duration was 59 months for recurrence and 84 months for mortality. Results: LN metastasis was found in 6.7% (18/270) of patients at surgery. Ulcer [odds ratio (OR) 3.83; 95% confidence interval (CI) 1.21-12.13; p = 0.022] and submucosal invasion (OR 10.35; 95% CI 1.35-79.48; p = 0.025) were independent risk factors. In the follow-up group, seven patients (1.9%) developed LN or distant recurrence. Ulcer [hazard ratio (HR) 7.60; 95% CI 1.39-35.74; p = 0.018], LVI (HR 6.80; 95% CI 1.07-42.99; p = 0.042), and positive vertical margin (HR 6.71; 95% CI 1.28-35.19; p = 0.024) were independent risk factors. In the overall cohort, LN metastasis rates were 9.6% in patients with two or more risk factors and 1.2% in those with no or one risk factor. Conclusions: LVI, ulcer, submucosal invasion, and positive vertical margin are independently associated with LN or distant metastasis after non-curative ER of undifferentiated-type EGC. Surgical resection is strongly recommended for patients with two or more risk factors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag Tokyo | - |
dc.relation.isPartOf | GASTRIC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Endoscopic Mucosal Resection* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrectomy* | - |
dc.subject.MESH | Gastric Mucosa / pathology | - |
dc.subject.MESH | Gastric Mucosa / surgery | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Nodes / pathology* | - |
dc.subject.MESH | Lymphatic Metastasis / pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Margins of Excision | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local / etiology | - |
dc.subject.MESH | Neoplasm Recurrence, Local / pathology | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Postoperative Period | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stomach Neoplasms / mortality | - |
dc.subject.MESH | Stomach Neoplasms / pathology* | - |
dc.subject.MESH | Stomach Neoplasms / surgery | - |
dc.title | Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyo-Joon Yang | - |
dc.contributor.googleauthor | Jae-Young Jang | - |
dc.contributor.googleauthor | Sang Gyun Kim | - |
dc.contributor.googleauthor | Ji Yong Ahn | - |
dc.contributor.googleauthor | Su Youn Nam | - |
dc.contributor.googleauthor | Jie-Hyun Kim | - |
dc.contributor.googleauthor | Byung-Hoon Min | - |
dc.contributor.googleauthor | Wan-Sik Lee | - |
dc.contributor.googleauthor | Bong Eun Lee | - |
dc.contributor.googleauthor | Moon Kyung Joo | - |
dc.contributor.googleauthor | Jae Myung Park | - |
dc.contributor.googleauthor | Woon Geon Shin | - |
dc.contributor.googleauthor | Hang Lak Lee | - |
dc.contributor.googleauthor | Tae-Geun Gweon | - |
dc.contributor.googleauthor | Moo In Park | - |
dc.contributor.googleauthor | Jeongmin Choi | - |
dc.contributor.googleauthor | Chung Hyun Tae | - |
dc.contributor.googleauthor | Young-Il Kim | - |
dc.contributor.googleauthor | Il Ju Choi | - |
dc.identifier.doi | 10.1007/s10120-020-01103-2 | - |
dc.contributor.localId | A00996 | - |
dc.relation.journalcode | J00916 | - |
dc.identifier.eissn | 1436-3305 | - |
dc.identifier.pmid | 32623585 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10120-020-01103-2 | - |
dc.subject.keyword | Lymph node Metastasis | - |
dc.subject.keyword | Non-curative resection | - |
dc.subject.keyword | Risk factors | - |
dc.subject.keyword | Stomach neoplasms | - |
dc.subject.keyword | Undifferentiated-type histology | - |
dc.contributor.alternativeName | Kim, Jie-Hyun | - |
dc.contributor.affiliatedAuthor | 김지현 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 168 | - |
dc.citation.endPage | 178 | - |
dc.identifier.bibliographicCitation | GASTRIC CANCER, Vol.24(1) : 168-178, 2021-01 | - |
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