Cited 5 times in
Proteinuria Is Associated with the Development of Crohn's Disease: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | 강은애 | - |
dc.date.accessioned | 2022-11-24T00:51:45Z | - |
dc.date.available | 2022-11-24T00:51:45Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191048 | - |
dc.description.abstract | Background and aims: The impact of proteinuria and its severity on the incidence of inflammatory bowel disease (IBD) has not yet been studied. We aimed to determine the association between proteinuria measured by urine dipstick tests and the development of IBD. Methods: This nationwide population-based study was conducted using the Korean National Health Insurance Service (NHIS) database. A total of 9,917,400 people aged 20 years or older who had undergone a national health examination conducted by the NHIS in 2009 were followed up until 2017. The study population was classified into four groups-negative, trace, 1+, and ≥ 2+-according to the degree of proteinuria measured by the urine dipstick test. The primary endpoint was newly diagnosed IBD, Crohn's disease (CD), or ulcerative colitis (UC) during the follow-up period. Results: Compared with the dipstick-negative group, the incidence of CD significantly increased according to the degree of proteinuria (adjusted hazard ratio [aHR] with 95% confidence interval [CI], 1.01 [0.703-1.451], 1.515 [1.058-2.162], and 2.053 [1.301-3.24] in the trace, 1+, and ≥ 2+ dipstick groups, respectively; p for trend 0.007). However, there was no significant difference in the incidence of UC according to the degree of proteinuria (aHR with 95% CI, 1.12 [0.949-1.323], 0.947 [0.764-1.174], and 1.009 [0.741-1.373] in the trace, 1+, and ≥ 2+ dipstick groups, respectively; p for trend 0.722). In the subgroup analysis, dipstick-positive proteinuria independently increased the incidence of CD regardless of the subgroup. However, dipstick-positive proteinuria was associated with the risk of UC in those with diabetes mellitus and not in those without diabetes mellitus (aHR, 1.527 vs. 0.846; interaction p-value 0.004). The risk of CD was increased or decreased according to proteinuria changes but not associated with the risk of UC. Conclusion: Proteinuria, measured by the dipstick test, is strongly associated with the development of CD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Proteinuria Is Associated with the Development of Crohn's Disease: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seona Park | - |
dc.contributor.googleauthor | Hyun Jung Lee | - |
dc.contributor.googleauthor | Kyung-Do Han | - |
dc.contributor.googleauthor | Hosim Soh | - |
dc.contributor.googleauthor | Jung Min Moon | - |
dc.contributor.googleauthor | Seung Wook Hong | - |
dc.contributor.googleauthor | Eun Ae Kang | - |
dc.contributor.googleauthor | Jong Pil Im | - |
dc.contributor.googleauthor | Joo Sung Kim | - |
dc.identifier.doi | 10.3390/jcm10040799 | - |
dc.contributor.localId | A05966 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 33669473 | - |
dc.subject.keyword | Crohn’s disease | - |
dc.subject.keyword | claims data | - |
dc.subject.keyword | incidence | - |
dc.subject.keyword | proteinuria | - |
dc.contributor.alternativeName | Kang, Eun Ae | - |
dc.contributor.affiliatedAuthor | 강은애 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 799 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.10(4) : 799, 2021-02 | - |
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