Cited 4 times in
Clinical outcomes of endoscopic resection for undifferentiated intramucosal early gastric cancer larger than 2 cm
DC Field | Value | Language |
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dc.contributor.author | 김지현 | - |
dc.date.accessioned | 2022-11-24T00:49:54Z | - |
dc.date.available | 2022-11-24T00:49:54Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191014 | - |
dc.description.abstract | Background: This study investigated the long-term clinical outcomes of endoscopic resection (ER) for undifferentiated-type (UD) early gastric cancer (EGC), with tumor size > 2 cm as the only non-curative factor. Methods: From among 1123 patients who underwent ER for UD EGC at 18 tertiary hospitals in Korea between 2005 and 2014, we identified 216 patients with UD intramucosal EGC > 2 cm, which was completely resected, with negative resection margins, and absence of ulceration and lymphovascular invasion. The patients were divided into the additional surgery (n = 40) or observation (n = 176) groups, according to post-ER management and were followed up for a median duration of 59 months for recurrence and 90 months for overall survival. Results: Lymph node (LN) or distant metastasis or cancer-related mortality was not observed in the surgery group. In the observation group, two (1.1%) patients developed LN or distant metastasis with a 5-year cumulative risk of 0.7%, and one (0.6%) patient died of gastric cancer. The 5- and 8-year overall survival rates were 94.1% and 89.9%, respectively, in the observation group and 100.0% and 95.2%, respectively, in the surgery group (log-rank P = 0.159). Cox regression analysis did not reveal an association between the observation group and increased mortality. Conclusion: The risk of LN or distant metastasis was not negligible, but as low as 1% for patients undergoing non-curative ER for UD EGC, with tumor size > 2 cm as the only non-curative factor. Close observation may be an alternative to surgery, especially for older patients or those with poor physical status. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag Tokyo | - |
dc.relation.isPartOf | GASTRIC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma / mortality | - |
dc.subject.MESH | Carcinoma / pathology* | - |
dc.subject.MESH | Endoscopic Mucosal Resection / methods | - |
dc.subject.MESH | Endoscopic Mucosal Resection / mortality* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrectomy / methods | - |
dc.subject.MESH | Gastrectomy / mortality* | - |
dc.subject.MESH | Gastric Mucosa / pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Nodes / pathology | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Margins of Excision | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stomach Neoplasms / mortality | - |
dc.subject.MESH | Stomach Neoplasms / pathology* | - |
dc.subject.MESH | Stomach Neoplasms / surgery* | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tumor Burden | - |
dc.title | Clinical outcomes of endoscopic resection for undifferentiated intramucosal early gastric cancer larger than 2 cm | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyo-Joon Yang | - |
dc.contributor.googleauthor | Su Youn Nam | - |
dc.contributor.googleauthor | Byung-Hoon Min | - |
dc.contributor.googleauthor | Ji Yong Ahn | - |
dc.contributor.googleauthor | Jae-Young Jang | - |
dc.contributor.googleauthor | Jung Kim | - |
dc.contributor.googleauthor | Jie-Hyun Kim | - |
dc.contributor.googleauthor | Wan-Sik Lee | - |
dc.contributor.googleauthor | Bong Eun Lee | - |
dc.contributor.googleauthor | Moon Kyung Joo | - |
dc.contributor.googleauthor | Jae Myung Park | - |
dc.contributor.googleauthor | Woon Geon Shin | - |
dc.contributor.googleauthor | Hang Lak Lee | - |
dc.contributor.googleauthor | Tae-Geun Gweon | - |
dc.contributor.googleauthor | Moo In Park | - |
dc.contributor.googleauthor | Jeongmin Choi | - |
dc.contributor.googleauthor | Chung Hyun Tae | - |
dc.contributor.googleauthor | Young-Il Kim | - |
dc.contributor.googleauthor | Il Ju Choi | - |
dc.identifier.doi | 10.1007/s10120-020-01115-y | - |
dc.contributor.localId | A00996 | - |
dc.relation.journalcode | J00916 | - |
dc.identifier.eissn | 1436-3305 | - |
dc.identifier.pmid | 32833124 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10120-020-01115-y | - |
dc.subject.keyword | Endoscopic mucosal resection | - |
dc.subject.keyword | Lymph node metastasis | - |
dc.subject.keyword | Stomach neoplasms | - |
dc.subject.keyword | Treatment outcome | - |
dc.subject.keyword | Undifferentiated-type histology | - |
dc.contributor.alternativeName | Kim, Jie-Hyun | - |
dc.contributor.affiliatedAuthor | 김지현 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 435 | - |
dc.citation.endPage | 444 | - |
dc.identifier.bibliographicCitation | GASTRIC CANCER, Vol.24(2) : 435-444, 2021-03 | - |
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