Cited 7 times in
Influenza-associated Neurologic Complications in Hospitalized Pediatric Patients: A Multicenter Retrospective Study in Republic of Korea
DC Field | Value | Language |
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dc.contributor.author | 최준식 | - |
dc.date.accessioned | 2022-11-24T00:47:03Z | - |
dc.date.available | 2022-11-24T00:47:03Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0891-3668 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190971 | - |
dc.description.abstract | Background: The rates of influenza-associated neurologic complications are variable among studies, and a difference has been observed between the Western and Asian countries. The study aims to evaluate the frequency and characteristics of influenza-associated neurologic complications. Methods: We performed a retrospective review of hospitalized cases of influenza infection from October 2010 to April 2017 from 3 referral hospitals. Results: A total of 1988 influenza cases were identified. Influenza-associated neurologic complications were 161 cases (8.1%); influenza virus A was detected in 113 (70.2%) cases, B in 47 (29.2%) cases and both A and B in 1 case (0.6%). Twenty-four patients (15%) had underlying neurologic diseases. The most common diagnosis was a simple febrile convulsion (44%), followed by complex febrile convulsion (29%), fever-provoked seizure under pre-existing neurologic disease or afebrile seizure (14%), encephalopathy/encephalitis (8%) and meningitis (5%). Most of the patients fully recovered (96%). Three patients (1.9%) died of myocarditis (n = 1), encephalopathy (n = 1), and simultaneous encephalitis and myocarditis (n = 1). Pre-existing neurologic disease, age groups of 6 months to 6 years and 6-12 years were a risk factor of influenza-associated neurologic complications with an adjusted odds ratio of 5.41 (95% confidence interval [CI] 3.23-9.06, P < 0.001), 12.99 (95% CI 1.77-95.19, P = 0.01) and 8.54 (95% CI 1.14-64.79, P = 0.04), respectively. There was no association between neuropsychiatric adverse events and oseltamivir prescription (P = 0.17). Conclusions: Influenza-associated neurologic complications are not uncommon, and most patients fully recovered. The frequency of influenza-associated neurologic complications in Korean children was not significantly different from that of children in Western countries. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Williams & Wilkins | - |
dc.relation.isPartOf | PEDIATRIC INFECTIOUS DISEASE JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Antiviral Agents / therapeutic use | - |
dc.subject.MESH | Brain Diseases / virology* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hospitalization / statistics & numerical data* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Influenza A Virus, H1N1 Subtype / pathogenicity | - |
dc.subject.MESH | Influenza, Human / complications* | - |
dc.subject.MESH | Influenza, Human / drug therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Oseltamivir / therapeutic use | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Seizures, Febrile / virology | - |
dc.title | Influenza-associated Neurologic Complications in Hospitalized Pediatric Patients: A Multicenter Retrospective Study in Republic of Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Gwang-Jun Choi | - |
dc.contributor.googleauthor | Ji Young Park | - |
dc.contributor.googleauthor | Joon-Sik Choi | - |
dc.contributor.googleauthor | Sae Rom Choi | - |
dc.contributor.googleauthor | Dongsub Kim | - |
dc.contributor.googleauthor | Jun Hwa Lee | - |
dc.contributor.googleauthor | Young-Jong Woo | - |
dc.contributor.googleauthor | Jeehun Lee | - |
dc.contributor.googleauthor | Yae-Jean Kim | - |
dc.identifier.doi | 10.1097/INF.0000000000003332 | - |
dc.contributor.localId | A06293 | - |
dc.relation.journalcode | J02487 | - |
dc.identifier.eissn | 1532-0987 | - |
dc.identifier.pmid | 34609108 | - |
dc.identifier.url | https://journals.lww.com/pidj/Fulltext/2021/12000/Influenza_associated_Neurologic_Complications_in.6.aspx | - |
dc.contributor.alternativeName | Choi, Joon Sik | - |
dc.contributor.affiliatedAuthor | 최준식 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | E466 | - |
dc.citation.endPage | E471 | - |
dc.identifier.bibliographicCitation | PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol.40(12) : E466-E471, 2021-12 | - |
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