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A Mixed-chimerism Protocol Utilizing Thymoglobulin and Belatacept Did Not Induce Lung Allograft Tolerance, Despite Previous Success in Renal Allotransplantation

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dc.contributor.author허규하-
dc.date.accessioned2022-11-24T00:44:25Z-
dc.date.available2022-11-24T00:44:25Z-
dc.date.issued2021-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190927-
dc.identifier.urihttps://journals.lww.com/transplantationdirect/fulltext/2021/06000/a_mixed_chimerism_protocol_utilizing_thymoglobulin.10.aspx-
dc.description.abstractBackground: In kidney transplantation, long-term allograft acceptance in cynomolgus macaques was achieved using a mixed-chimerism protocol based on the clinically available reagents, rabbit anti-thymocyte globulin (ATG), and belatacept. Here, we have tested the same protocol in cynomolgus macaques transplanted with fully allogeneic lung grafts. Methods: Five cynomolgus macaques underwent left orthotopic lung transplantation. Initial immunosuppression included equine ATG and anti-IL6RmAb induction, followed by triple-drug immunosuppression for 4 mo. Post-transplant, a nonmyeloablative conditioning regimen was applied, including total body and thymic irradiation. Rabbit ATG, belatacept, anti-IL6RmAb, and donor bone marrow transplantation (DBMT) were given, in addition to a 28-d course of cyclosporine. All immunosuppressant drugs were stopped on day 29 after DBMT. Results: One monkey rejected its lung before DBMT due to AMR, after developing donor-specific antibodies. Two monkeys developed fatal post-transplant lymphoproliferative disorder, and both monkeys had signs of cellular rejection in their allografts upon autopsy. The remaining 2 monkeys showed severe cellular rejection on days 42 and 70 post-DBMT. Cytokine analysis suggested higher levels of pro-inflammatory markers in the lung transplant cohort, as compared to kidney recipients. Conclusion: Although the clinically applicable protocol showed success in kidney transplantation, the study did not show long-term survival in a lung transplant model, highlighting the organ-specific differences in tolerance induction.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWolters Kluwer-
dc.relation.isPartOfTRANSPLANTATION DIRECT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleA Mixed-chimerism Protocol Utilizing Thymoglobulin and Belatacept Did Not Induce Lung Allograft Tolerance, Despite Previous Success in Renal Allotransplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorWiebke Sommer-
dc.contributor.googleauthorJane M O-
dc.contributor.googleauthorKurt B Pruner-
dc.contributor.googleauthorAbbas Dehnadi-
dc.contributor.googleauthorKyu Ha Huh-
dc.contributor.googleauthorKortney A Robinson-
dc.contributor.googleauthorIsabel Hanekamp-
dc.contributor.googleauthorIvy Rosales-
dc.contributor.googleauthorAlison S Bean-
dc.contributor.googleauthorJosh Paster-
dc.contributor.googleauthorTetsu Oura-
dc.contributor.googleauthorRex Neal Smith-
dc.contributor.googleauthorRobert Colvin-
dc.contributor.googleauthorGilles Benichou-
dc.contributor.googleauthorTatsuo Kawai-
dc.contributor.googleauthorJoren C Madsen-
dc.contributor.googleauthorJames S Allan-
dc.identifier.doi10.1097/TXD.0000000000001150-
dc.contributor.localIdA04344-
dc.relation.journalcodeJ03551-
dc.identifier.eissn2373-8731-
dc.identifier.pmid34056080-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthor허규하-
dc.citation.volume7-
dc.citation.number6-
dc.citation.startPagee705-
dc.identifier.bibliographicCitationTRANSPLANTATION DIRECT, Vol.7(6) : e705, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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