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A Mixed-chimerism Protocol Utilizing Thymoglobulin and Belatacept Did Not Induce Lung Allograft Tolerance, Despite Previous Success in Renal Allotransplantation
DC Field | Value | Language |
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dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2022-11-24T00:44:25Z | - |
dc.date.available | 2022-11-24T00:44:25Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190927 | - |
dc.identifier.uri | https://journals.lww.com/transplantationdirect/fulltext/2021/06000/a_mixed_chimerism_protocol_utilizing_thymoglobulin.10.aspx | - |
dc.description.abstract | Background: In kidney transplantation, long-term allograft acceptance in cynomolgus macaques was achieved using a mixed-chimerism protocol based on the clinically available reagents, rabbit anti-thymocyte globulin (ATG), and belatacept. Here, we have tested the same protocol in cynomolgus macaques transplanted with fully allogeneic lung grafts. Methods: Five cynomolgus macaques underwent left orthotopic lung transplantation. Initial immunosuppression included equine ATG and anti-IL6RmAb induction, followed by triple-drug immunosuppression for 4 mo. Post-transplant, a nonmyeloablative conditioning regimen was applied, including total body and thymic irradiation. Rabbit ATG, belatacept, anti-IL6RmAb, and donor bone marrow transplantation (DBMT) were given, in addition to a 28-d course of cyclosporine. All immunosuppressant drugs were stopped on day 29 after DBMT. Results: One monkey rejected its lung before DBMT due to AMR, after developing donor-specific antibodies. Two monkeys developed fatal post-transplant lymphoproliferative disorder, and both monkeys had signs of cellular rejection in their allografts upon autopsy. The remaining 2 monkeys showed severe cellular rejection on days 42 and 70 post-DBMT. Cytokine analysis suggested higher levels of pro-inflammatory markers in the lung transplant cohort, as compared to kidney recipients. Conclusion: Although the clinically applicable protocol showed success in kidney transplantation, the study did not show long-term survival in a lung transplant model, highlighting the organ-specific differences in tolerance induction. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wolters Kluwer | - |
dc.relation.isPartOf | TRANSPLANTATION DIRECT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | A Mixed-chimerism Protocol Utilizing Thymoglobulin and Belatacept Did Not Induce Lung Allograft Tolerance, Despite Previous Success in Renal Allotransplantation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Wiebke Sommer | - |
dc.contributor.googleauthor | Jane M O | - |
dc.contributor.googleauthor | Kurt B Pruner | - |
dc.contributor.googleauthor | Abbas Dehnadi | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Kortney A Robinson | - |
dc.contributor.googleauthor | Isabel Hanekamp | - |
dc.contributor.googleauthor | Ivy Rosales | - |
dc.contributor.googleauthor | Alison S Bean | - |
dc.contributor.googleauthor | Josh Paster | - |
dc.contributor.googleauthor | Tetsu Oura | - |
dc.contributor.googleauthor | Rex Neal Smith | - |
dc.contributor.googleauthor | Robert Colvin | - |
dc.contributor.googleauthor | Gilles Benichou | - |
dc.contributor.googleauthor | Tatsuo Kawai | - |
dc.contributor.googleauthor | Joren C Madsen | - |
dc.contributor.googleauthor | James S Allan | - |
dc.identifier.doi | 10.1097/TXD.0000000000001150 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J03551 | - |
dc.identifier.eissn | 2373-8731 | - |
dc.identifier.pmid | 34056080 | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | e705 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION DIRECT, Vol.7(6) : e705, 2021-05 | - |
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