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Emerging Brain-Pathophysiology-Mimetic Platforms for Studying Neurodegenerative Diseases: Brain Organoids and Brains-on-a-Chip

Authors
 Seokyoung Bang  ;  Songhyun Lee  ;  Nakwon Choi  ;  Hong Nam Kim 
Citation
 ADVANCED HEALTHCARE MATERIALS, Vol.10(12) : 2002119, 2021-06 
Journal Title
ADVANCED HEALTHCARE MATERIALS
ISSN
 2192-2640 
Issue Date
2021-06
MeSH
Animals ; Brain ; Brain Diseases* ; Humans ; Lab-On-A-Chip Devices ; Neurodegenerative Diseases* ; Organoids
Keywords
biomimetic matericals ; brain organoids ; brain spheroids ; brains-on-a-chip ; neurodegenerative diseases ; pathophysiology
Abstract
Neurodegenerative diseases are a group of disorders characterized by progressive degeneration of the structural and functional integrity of the central and peripheral nervous systems. Millions of people suffer from degenerative brain diseases worldwide, and the mortality continues to increase every year, causing a growing demand for knowledge of the underlying mechanisms and development of therapeutic targets. Conventional 2D-based cell culture platforms and animal models cannot fully recapitulate the pathophysiology, and this has limited the capability for estimating drug efficacy. Recently, engineered platforms, including brain organoids and brain-on-a-chip, have emerged. They mimic the physiology of brain tissue and reflect the fundamental pathophysiological signatures of neurodegenerative diseases, such as the accumulation of neurotoxic proteins, structural abnormalities, and functional loss. In this paper, recent advances in brain-mimetic platforms and their potential for modeling features of neurodegenerative diseases in vitro are reviewed. The development of a physiologically relevant model should help overcome unresolved neurodegenerative diseases.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/adhm.202002119
DOI
10.1002/adhm.202002119
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Lee, Songhyun(이송현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190880
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