Cited 4 times in
Clinical characteristics of non-radiographic axial spondyloarthritis: Results of the Korean Nonradiographic Axial SPondyloArthritis (KONASPA) data
DC Field | Value | Language |
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dc.contributor.author | 박민찬 | - |
dc.date.accessioned | 2022-11-24T00:35:24Z | - |
dc.date.available | 2022-11-24T00:35:24Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190788 | - |
dc.description.abstract | Aim: To evaluate clinical characteristics and natural history of non-radiographic axial spondyloarthritis (nr-axSpA) using KOrean Nonradiographic Axial SPondyloArthritis (KONASPA) data. Methods: Data were collected from 11 centers in South Korea. A total of 278 patients with nr-axSpA from January 2018 to July 2020 were included. Demographic data, clinical features, comorbidities, disease activity, medications, and laboratory results were collected. Results: Mean age at symptom onset was 28.2 ± 14.2 years. Of 278 patients, 152 (54.7%) were male. Mean Bath Ankylosing Spondylitis Disease Activity Index at diagnosis was 3.5 ± 2.1. Dyslipidemia was the most common comorbidity (8.4%), followed by hypertension (6.1%). Mean age at diagnosis of nr-axSpA was older in female patients than in male patients (31.8 ± 15.8 years vs 24.9 ± 12.0 years, P < 0.001). Enthesitis and uveitis were more frequently found in female patients than in male patients. Thirty-one (11.1%) participants with nr-axSpA progressed to ankylosing spondylitis. The median follow-up duration was 48 months. In multivariable Cox regression analysis, age at symptom onset (hazard ratio [HR] 0.93, 95% confidence interval (CI) 0.88-0.97, P = 0.006), body mass index (BMI) (HR 1.24, 95% CI 1.06-1.44, P = 0.005) and sacroiliitis grade (HR 1.86, 95% CI 1.19-2.92, P = 0.006) were associated with progression to ankylosing spondylitis. Conclusions: Results of nationwide data revealed that women with nr-axSpA showed a late disease onset and more extra-articular manifestations than men. Young age at symptom onset, high BMI, and presence of radiographic sacroiliitis at diagnosis were risk factors for progression to AS. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley on behalf of the Asia Pacific League of Associations for Rheumatology | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Axial Spondyloarthritis / diagnosis* | - |
dc.subject.MESH | Axial Spondyloarthritis / epidemiology | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Databases, Factual | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sacroiliitis / diagnosis* | - |
dc.subject.MESH | Sacroiliitis / epidemiology | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Young Adult | - |
dc.title | Clinical characteristics of non-radiographic axial spondyloarthritis: Results of the Korean Nonradiographic Axial SPondyloArthritis (KONASPA) data | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyemin Jeong | - |
dc.contributor.googleauthor | Yong-Gil Kim | - |
dc.contributor.googleauthor | Tae-Hwan Kim | - |
dc.contributor.googleauthor | Tae-Jong Kim | - |
dc.contributor.googleauthor | Min-Chan Park | - |
dc.contributor.googleauthor | Mi Ryoung Seo | - |
dc.contributor.googleauthor | Kichul Shin | - |
dc.contributor.googleauthor | Ji Seon Oh | - |
dc.contributor.googleauthor | Sang-Hoon Lee | - |
dc.contributor.googleauthor | Yeon-Ah Lee | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Han Joo Baek | - |
dc.contributor.googleauthor | Hoon-Suk Cha | - |
dc.identifier.doi | 10.1111/1756-185X.14175 | - |
dc.contributor.localId | A01470 | - |
dc.relation.journalcode | J01158 | - |
dc.identifier.eissn | 1756-185X | - |
dc.identifier.pmid | 34250745 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.14175 | - |
dc.subject.keyword | ankylosing spondylitis | - |
dc.subject.keyword | body mass index | - |
dc.subject.keyword | disease progression | - |
dc.subject.keyword | sacroiliitis | - |
dc.subject.keyword | spondyloarthritis | - |
dc.contributor.alternativeName | Park, Min Chan | - |
dc.contributor.affiliatedAuthor | 박민찬 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1137 | - |
dc.citation.endPage | 1147 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.24(9) : 1137-1147, 2021-09 | - |
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