Cited 4 times in
Photochemical reaction to increase melanogenesis using Buddleja officinalis and blue light-emitting diode irradiation in B16F10
DC Field | Value | Language |
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dc.contributor.author | 조혜중 | - |
dc.date.accessioned | 2022-11-24T00:35:09Z | - |
dc.date.available | 2022-11-24T00:35:09Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1572-1000 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190785 | - |
dc.description.abstract | Recently, the incidence of vitiligo has increased because of stresses induced by external environment. Ultraviolet (UV) light therapy is the most commonly used method of treating the disease; however, UV light therapy requires a long treatment period, and prolonged exposure to UV radiation has side effects. The purpose of the present study was to investigate the effects of natural products and LED irradiation (LED-IR) on the synthesis of melanin. It was not possible to effectively increase intracellular melanin production through individual applications of Buddleja officinalis (BO), which is a natural substance selected through screening, or blue light irradiation (Blue-IR). However, when used in combination, these two agents stimulated adenylyl cyclase (AC) and melanin production was induced in the stimulated cells via the CREB/MITF/TYR pathway. Furthermore, the combined treatment with BO and Blue-IR generated low levels of cellular reactive oxygen species (ROS) and induced p38 phosphorylation, which in turn activated MITF in ROS-stimulated synthetic melanocytes, resulting in the promotion of melanogenic pathways other than the CREB/MITF/TYR pathway. In addition, this treatment combination effected melanin transport. These results suggested that the combined therapies can be used to treat melanin-deficiency skin diseases such as vitiligo. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Buddleja* | - |
dc.subject.MESH | Melanins | - |
dc.subject.MESH | Melanocytes | - |
dc.subject.MESH | Photochemotherapy* / methods | - |
dc.subject.MESH | Photosensitizing Agents | - |
dc.title | Photochemical reaction to increase melanogenesis using Buddleja officinalis and blue light-emitting diode irradiation in B16F10 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Hyejoung Cho | - |
dc.contributor.googleauthor | Byunggook Kim | - |
dc.contributor.googleauthor | Ok-Su Kim | - |
dc.contributor.googleauthor | Young Kim | - |
dc.contributor.googleauthor | Ying Yang | - |
dc.contributor.googleauthor | Jianan Song | - |
dc.contributor.googleauthor | Danyang Liu | - |
dc.contributor.googleauthor | Sangmi Jeon | - |
dc.contributor.googleauthor | Okjoon Kim | - |
dc.identifier.doi | 10.1016/j.pdpdt.2021.102456 | - |
dc.contributor.localId | A06331 | - |
dc.relation.journalcode | J02519 | - |
dc.identifier.eissn | 1873-1597 | - |
dc.identifier.pmid | 34311092 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1572100021002805 | - |
dc.subject.keyword | Blue Light emitting diode irradiation | - |
dc.subject.keyword | Buddleja officinalis | - |
dc.subject.keyword | Melanogenesis | - |
dc.subject.keyword | Photochemotherapy | - |
dc.subject.keyword | Vitiligo | - |
dc.contributor.alternativeName | Cho, Hyejoung | - |
dc.contributor.affiliatedAuthor | 조혜중 | - |
dc.citation.volume | 35 | - |
dc.citation.startPage | 102456 | - |
dc.identifier.bibliographicCitation | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, Vol.35 : 102456, 2021-09 | - |
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