Cited 5 times in
Upstaging and Survival Outcomes for Non-Muscle Invasive Bladder Cancer After Radical Cystectomy: Results from the International Robotic Cystectomy Consortium
DC Field | Value | Language |
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dc.contributor.author | 나군호 | - |
dc.date.accessioned | 2022-11-24T00:32:24Z | - |
dc.date.available | 2022-11-24T00:32:24Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0892-7790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190753 | - |
dc.description.abstract | Introduction: We sought to describe the incidence, risk factors, and survival outcomes associated with pathologic upstaging from non-muscle invasive bladder cancer (NMIBC) to muscle invasive bladder cancer (MIBC) after robot-assisted radical cystectomy (RARC). Methods: We reviewed the International Robotic Cystectomy Consortium database between 2004 and 2020. Upstaging was defined as ≥pT2 or pathologic node positive (pN+) at final pathology analysis from clinical <T2N0M0. Descriptive statistics were used to summarize data. Cochran-Armitage test was used to depict upstaging trend over time. Multivariate regression models were used to depict variables associated with upstaging. Kaplan-Meier curves were used to describe disease-specific survival (DSS), recurrence-free survival (RFS), and overall survival (OS). Results: A total of 463 patients underwent RARC for NMIBC. Upstaging occurred in 145 (31%) patients. Upstaged patients were older (70 vs 67 years, p < 0.01), more likely to have American Society of Anesthesiologists (ASA) score (≥3; 55% vs 44%, p = 0.04), and had higher rate of preoperative hydronephrosis (26% vs 10%, p < 0.01). They were more likely to have positive surgical margins (10% vs 3%, p = 0.01), recurrences (28% vs 9%, p < 0.01), and to receive adjuvant/salvage treatment (26% vs 3%, p < 0.01). On multivariate analysis, upstaging was associated with older age (odds ratio [OR] 1.04; confidence interval [CI] 1.01-1.07, p < 0.01), cT1 vs cTis (OR 4.25; CI 1.57-11.48, p < 0.01), cT1 vs cTa (OR 2.92; CI 1.40-6.06, p < 0.01), and preoperative hydronephrosis (OR 3.18; CI 1.60-6.32, p < 0.01). Upstaged patients had worse 5-year RFS (53% vs 85%, log rank p < 0.01), DSS (66% vs 93%, log rank p < 0.01), and OS (49% vs 74%, log rank p < 0.01). The rate of upstaging did not significantly change over time (38% in 2004 to 27% in 2019, p = 0.17). Conclusion: Upstaging to MIBC occurred in a significant proportion of patients after RARC for NMIBC and was associated with worse survival outcomes. Older patients, those with cT1 disease and hydronephrosis were more likely to upstage. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mary Ann Liebert | - |
dc.relation.isPartOf | JOURNAL OF ENDOUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cystectomy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Robotic Surgical Procedures* | - |
dc.subject.MESH | Robotics* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Urinary Bladder Neoplasms* / surgery | - |
dc.title | Upstaging and Survival Outcomes for Non-Muscle Invasive Bladder Cancer After Radical Cystectomy: Results from the International Robotic Cystectomy Consortium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Umar Iqbal | - |
dc.contributor.googleauthor | Ahmed S Elsayed | - |
dc.contributor.googleauthor | Zhe Jing | - |
dc.contributor.googleauthor | Michael Stöckle | - |
dc.contributor.googleauthor | Carl Wijburg | - |
dc.contributor.googleauthor | Peter Wiklund | - |
dc.contributor.googleauthor | Abolfazl Hosseini | - |
dc.contributor.googleauthor | Prokar Dasgupta | - |
dc.contributor.googleauthor | Mohammad Shamim Khan | - |
dc.contributor.googleauthor | Ashok Hemal | - |
dc.contributor.googleauthor | Eric Kim | - |
dc.contributor.googleauthor | Andrew A Wagner | - |
dc.contributor.googleauthor | Franco Gaboardi | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Thomas J Maatman | - |
dc.contributor.googleauthor | Derya Balbay | - |
dc.contributor.googleauthor | Qiang Li | - |
dc.contributor.googleauthor | Ahmed A Hussein | - |
dc.contributor.googleauthor | Khurshid A Guru | - |
dc.identifier.doi | 10.1089/end.2021.0013 | - |
dc.contributor.localId | A01227 | - |
dc.relation.journalcode | J01394 | - |
dc.identifier.eissn | 1557-900X | - |
dc.identifier.pmid | 34139890 | - |
dc.identifier.url | https://www.liebertpub.com/doi/10.1089/end.2021.0013 | - |
dc.subject.keyword | bladder cancer | - |
dc.subject.keyword | non-muscle invasive | - |
dc.subject.keyword | pathologic discrepancy | - |
dc.subject.keyword | radical cystectomy | - |
dc.subject.keyword | robot-assisted | - |
dc.subject.keyword | upstaging | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | 나군호 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1541 | - |
dc.citation.endPage | 1547 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENDOUROLOGY, Vol.35(10) : 1541-1547, 2021-10 | - |
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