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A Profile of Glucose-6-Phosphate Dehydrogenase Variants and Deficiency of Multicultural Families in Korea

DC Field Value Language
dc.contributor.author염준섭-
dc.date.accessioned2022-11-24T00:32:16Z-
dc.date.available2022-11-24T00:32:16Z-
dc.date.issued2021-10-
dc.identifier.issn0023-4001-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190749-
dc.description.abstractVivax malaria incidence in Korea is now decreased and showing a low plateau. Nowadays, vivax malaria in Korea is expected to be successfully eliminated with anti-malaria chemotherapy, primaquine, and vector control. The glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with potential hemolytic anemia after primaquine administration. This inborn disorder has a pivotal polymorphism with genetic variants and is the most prevalent X-chromosome-linked disorder. The prevalence of G6PD deficiency was previously reported negligible in Korea. As the population of multicultural families pertaining marriage immigrants and their adolescents increases, it is necessary to check G6PD deficiency for them prior to primaquine treatment for vivax malaria. The prevalence of G6PD variants and G6PD deficiency in multicultural families was performed in 7 counties and 2 cities of Jeollanam-do (Province), Gyeonggi-do, and Gangwon-do. A total of 733 blood samples of multicultural family participants were subjected to test the phenotypic and genetic G6PD deficiency status using G6PD enzyme activity quantitation kit and PCR-based G6PD genotyping kit. The G6PD phenotypic deficiency was observed in 7.8% of male adolescent participants and 3.2% of materfamilias population. Based on the PCR-based genotyping, we observed total 35 participants carrying the mutated alleles. It is proposed that primaquine prescription should seriously be considered prior to malaria treatment.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherKorean Society for Parasitology-
dc.relation.isPartOfKOREAN JOURNAL OF PARASITOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdolescent-
dc.subject.MESHAntimalarials* / therapeutic use-
dc.subject.MESHGlucosephosphate Dehydrogenase / genetics-
dc.subject.MESHGlucosephosphate Dehydrogenase / therapeutic use-
dc.subject.MESHGlucosephosphate Dehydrogenase Deficiency* / drug therapy-
dc.subject.MESHGlucosephosphate Dehydrogenase Deficiency* / epidemiology-
dc.subject.MESHGlucosephosphate Dehydrogenase Deficiency* / genetics-
dc.subject.MESHHumans-
dc.subject.MESHMalaria, Vivax* / drug therapy-
dc.subject.MESHMalaria, Vivax* / epidemiology-
dc.subject.MESHMale-
dc.subject.MESHPrimaquine-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.titleA Profile of Glucose-6-Phosphate Dehydrogenase Variants and Deficiency of Multicultural Families in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYoung Yil Bahk-
dc.contributor.googleauthorSeong Kyu Ahn-
dc.contributor.googleauthorJinyoung Lee-
dc.contributor.googleauthorJae Hyoung Im-
dc.contributor.googleauthorJoon-Sup Yeom-
dc.contributor.googleauthorSookkyung Park-
dc.contributor.googleauthorJeongran Kwon-
dc.contributor.googleauthorHyesu Kan-
dc.contributor.googleauthorMiyoung Kim-
dc.contributor.googleauthorWoori Jang-
dc.contributor.googleauthorTong-Soo Kim-
dc.identifier.doi10.3347/kjp.2021.59.5.447-
dc.contributor.localIdA02353-
dc.relation.journalcodeJ01957-
dc.identifier.eissn1738-0006-
dc.identifier.pmid34724763-
dc.subject.keywordG6PD deficiency-
dc.subject.keywordKorea-
dc.subject.keywordmulticultural family-
dc.subject.keywordprimaquine-
dc.contributor.alternativeNameYeom, Joon Sup-
dc.contributor.affiliatedAuthor염준섭-
dc.citation.volume59-
dc.citation.number5-
dc.citation.startPage447-
dc.citation.endPage455-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF PARASITOLOGY, Vol.59(5) : 447-455, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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