Cited 9 times in
A Basic Domain-Derived Tripeptide Inhibits MITF Activity by Reducing its Binding to the Promoter of Genes
DC Field | Value | Language |
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dc.contributor.author | 최지원 | - |
dc.date.accessioned | 2022-11-24T00:30:26Z | - |
dc.date.available | 2022-11-24T00:30:26Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190725 | - |
dc.description.abstract | The keratinocytes in UV-irradiated skin produce and secrete α-melanocyte-stimulating hormone. α-Melanocyte-stimulating hormone upregulates the expression of MITF in melanocytes through the cAMP‒protein kinase A‒CREB signaling pathway. Thereafter, MITF induces the expression of melanogenic genes, including the tyrosinase gene TYR and TYRP-1 and TYRP-2 genes, which leads to the synthesis and accumulation of melanin. In this study, we examined whether MITF basic region-derived tripeptides can bind to the DNA-binding domain of MITF and inhibit MITF-induced melanogenesis through the inhibition of MITF‒DNA binding. MITF-KGR, a representative MITF-derived tripeptide, suppressed the transcriptional activity of MITF by disrupting its binding to the promoter region of the target genes, which resulted in the inhibition of skin epidermis thickness and melanin synthesis in vivo and in vitro. Our results indicate that MITF-KGR exerts an inhibitory effect on melanogenesis by targeting MITF. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | DNA / metabolism | - |
dc.subject.MESH | Intramolecular Oxidoreductases / genetics | - |
dc.subject.MESH | Melanins / biosynthesis | - |
dc.subject.MESH | Membrane Glycoproteins / genetics | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Microphthalmia-Associated Transcription Factor / antagonists & inhibitors* | - |
dc.subject.MESH | Microphthalmia-Associated Transcription Factor / metabolism | - |
dc.subject.MESH | Monophenol Monooxygenase / genetics | - |
dc.subject.MESH | Oxidoreductases / genetics | - |
dc.subject.MESH | Peptide Fragments / pharmacology* | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.subject.MESH | Ultraviolet Rays | - |
dc.subject.MESH | alpha-MSH / antagonists & inhibitors | - |
dc.title | A Basic Domain-Derived Tripeptide Inhibits MITF Activity by Reducing its Binding to the Promoter of Genes | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학교실) | - |
dc.contributor.googleauthor | Dongyoung Lim | - |
dc.contributor.googleauthor | Kyoung-Jin Lee | - |
dc.contributor.googleauthor | Yuri Kim | - |
dc.contributor.googleauthor | Minseo Kim | - |
dc.contributor.googleauthor | Hyun-Mi Ju | - |
dc.contributor.googleauthor | Myoung-Ju Kim | - |
dc.contributor.googleauthor | Dong-Hwa Choi | - |
dc.contributor.googleauthor | Jiwon Choi | - |
dc.contributor.googleauthor | Suree Kim | - |
dc.contributor.googleauthor | Dongmin Kang | - |
dc.contributor.googleauthor | Kyoungyul Lee | - |
dc.contributor.googleauthor | Jang-Hee Hahn | - |
dc.identifier.doi | 10.1016/j.jid.2021.01.037 | - |
dc.contributor.localId | A06008 | - |
dc.relation.journalcode | J01469 | - |
dc.identifier.eissn | 1523-1747 | - |
dc.identifier.pmid | 33823181 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0022202X21011337 | - |
dc.contributor.alternativeName | Choi, Jiwon | - |
dc.contributor.affiliatedAuthor | 최지원 | - |
dc.citation.volume | 141 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2459 | - |
dc.citation.endPage | 2469 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol.141(10) : 2459-2469, 2021-10 | - |
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