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Targeting PLD2 in adipocytes augments adaptive thermogenesis by improving mitochondrial quality and quantity in mice

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dc.contributor.author강은석-
dc.contributor.author이민영-
dc.date.accessioned2022-09-14T01:52:52Z-
dc.date.available2022-09-14T01:52:52Z-
dc.date.issued2021-12-
dc.identifier.issn0022-1007-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190662-
dc.description.abstractPhospholipase D (PLD)2 via its enzymatic activity regulates cell proliferation and migration and thus is implicated in cancer. However, the role of PLD2 in obesity and type 2 diabetes has not previously been investigated. Here, we show that during diet-induced thermogenesis and obesity, levels of PLD2 but not PLD1 in adipose tissue are inversely related with uncoupling protein 1, a key thermogenic protein. We demonstrate that the thermogenic program in adipose tissue is significantly augmented in mice with adipocyte-specific Pld2 deletion or treated with a PLD2-specific inhibitor and that these mice are resistant to high fat diet-induced obesity, glucose intolerance, and insulin resistance. Mechanistically, we show that Pld2 deletion in adipose tissue or PLD2 pharmacoinhibition acts via p62 to improve mitochondrial quality and quantity in adipocytes. Thus, PLD2 inhibition is an attractive therapeutic approach for obesity and type 2 diabetes by resolving defects in diet-induced thermogenesis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherRockefeller University Press-
dc.relation.isPartOfJOURNAL OF EXPERIMENTAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdipocytes / metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHBiomarkers-
dc.subject.MESHBlood Glucose-
dc.subject.MESHDiet, High-Fat-
dc.subject.MESHEnergy Metabolism-
dc.subject.MESHEnzyme Inhibitors / pharmacology-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMitochondria / genetics*-
dc.subject.MESHMitochondria / metabolism*-
dc.subject.MESHMitochondria / ultrastructure-
dc.subject.MESHObesity / etiology-
dc.subject.MESHObesity / metabolism-
dc.subject.MESHPhospholipase D / antagonists & inhibitors-
dc.subject.MESHPhospholipase D / genetics*-
dc.subject.MESHPhospholipase D / metabolism-
dc.subject.MESHProteasome Endopeptidase Complex / metabolism-
dc.subject.MESHThermogenesis / genetics*-
dc.subject.MESHUncoupling Protein 1 / genetics-
dc.subject.MESHUncoupling Protein 1 / metabolism-
dc.titleTargeting PLD2 in adipocytes augments adaptive thermogenesis by improving mitochondrial quality and quantity in mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHyung Sik Kim-
dc.contributor.googleauthorMin Young Park-
dc.contributor.googleauthorNam Joo Yun-
dc.contributor.googleauthorHye Sun Go-
dc.contributor.googleauthorMi Young Kim-
dc.contributor.googleauthorJe Kyung Seong-
dc.contributor.googleauthorMinyoung Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorJaewang Ghim-
dc.contributor.googleauthorSung Ho Ryu-
dc.contributor.googleauthorBrian A Zabel-
dc.contributor.googleauthorAra Koh-
dc.contributor.googleauthorYoe-Sik Bae-
dc.identifier.doi10.1084/jem.20211523-
dc.contributor.localIdA00068-
dc.contributor.localIdA05491-
dc.relation.journalcodeJ01409-
dc.identifier.eissn1540-9538-
dc.identifier.pmid34940790-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.affiliatedAuthor강은석-
dc.contributor.affiliatedAuthor이민영-
dc.citation.volume219-
dc.citation.number2-
dc.citation.startPagee20211523-
dc.identifier.bibliographicCitationJOURNAL OF EXPERIMENTAL MEDICINE, Vol.219(2) : e20211523, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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