Cited 5 times in
Role of VVZ-149, a Novel Analgesic Molecule, in the Affective Component of Pain: Results from an Exploratory Proof-of-Concept Study of Postoperative Pain following Laparoscopic and Robotic-Laparoscopic Gastrectomy
DC Field | Value | Language |
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dc.contributor.author | 배선준 | - |
dc.date.accessioned | 2022-09-14T01:34:18Z | - |
dc.date.available | 2022-09-14T01:34:18Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1526-2375 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190523 | - |
dc.description.abstract | Objective: VVZ-149 is a small molecule that both inhibits the glycine transporter type 2 and the serotonin receptor 5 hydroxytryptamine 2 A. In a randomized, parallel-group, and double-blind trial (NCT02844725), we investigated the analgesic efficacy and safety of VVZ-149 Injections, which is under clinical development as a single-use injectable product for treating moderate to severe postoperative pain. Methods: Sixty patients undergoing laparoscopic and robotic-laparoscopic gastrectomy were randomly assigned to receive a 10-hour intravenous infusion of VVZ-149 Injections or placebo, initiated approximately 1 hour before completion of surgical suturing. Major outcomes included pain intensity and opioid consumption via patient-controlled analgesia and rescue analgesia provided "as needed." The treatment efficacy of VVZ-149 was further examined in a subpopulation requiring early rescue medication, previously associated with the presence of high levels of preoperative negative affect in a prior Phase 2 study (NCT02489526). Results: Pain intensity was lower in the VVZ-149 (n = 30) than the placebo group (n = 29), reaching statistical significance at 4 hours post-emergence (P < .05), with a 29.5% reduction in opioid consumption for 24 hours and fewer demands for patient-controlled analgesia. In the rescued subgroup, VVZ-149 further reduced pain intensity (P < .05) with 32.6% less opioid consumption for 24 hours compared to placebo patients. Conclusions: VVZ-149 demonstrated effective analgesia with reduced postoperative pain and opioid requirements. Consistent with the results from the previous Phase 2 study, patients with early rescue requirement had greater benefit from VVZ-149, supporting the hypothesis that VVZ-149 may alleviate the affective component of pain and mitigate excessive use of opioids postoperatively. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press on behalf of the American Academy of Pain Medicine | - |
dc.relation.isPartOf | PAIN MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Analgesics / therapeutic use | - |
dc.subject.MESH | Gastrectomy / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Laparoscopy* | - |
dc.subject.MESH | Pain, Postoperative / drug therapy | - |
dc.subject.MESH | Robotic Surgical Procedures* / adverse effects | - |
dc.title | Role of VVZ-149, a Novel Analgesic Molecule, in the Affective Component of Pain: Results from an Exploratory Proof-of-Concept Study of Postoperative Pain following Laparoscopic and Robotic-Laparoscopic Gastrectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Inkyung Song | - |
dc.contributor.googleauthor | Sunyoung Cho | - |
dc.contributor.googleauthor | Srdjan S Nedeljkovic | - |
dc.contributor.googleauthor | Sang Rim Lee | - |
dc.contributor.googleauthor | Chaewon Lee | - |
dc.contributor.googleauthor | Jina Kim | - |
dc.contributor.googleauthor | Sun Joon Bai | - |
dc.identifier.doi | 10.1093/pm/pnab066 | - |
dc.contributor.localId | A01795 | - |
dc.relation.journalcode | J02459 | - |
dc.identifier.eissn | 1526-4637 | - |
dc.identifier.pmid | 33624798 | - |
dc.identifier.url | https://academic.oup.com/painmedicine/article/22/9/2037/6149133 | - |
dc.contributor.alternativeName | Bai, Sun Joon | - |
dc.contributor.affiliatedAuthor | 배선준 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2037 | - |
dc.citation.endPage | 2049 | - |
dc.identifier.bibliographicCitation | PAIN MEDICINE, Vol.22(9) : 2037-2049, 2021-09 | - |
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