Cited 2 times in
Association between physical activity and inflammatory markers in community-dwelling, middle-aged adults
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.date.accessioned | 2022-09-14T01:26:35Z | - |
dc.date.available | 2022-09-14T01:26:35Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1715-5312 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190448 | - |
dc.description.abstract | Physical activity has been known to deter inflammatory process; yet, the evidence is scarce in healthy, middle-aged population. We assessed the association between physical activity and inflammatory biomarkers, including high sensitivity (hs) C-reactive protein, interleukin (IL)-1α, -1β, and -6, tumor necrosis factor (TNF) -α and -β, and monocyte chemotactic protein (MCP) -1 and -3. Functional and leisure-time physical activity was assessed by the International Physical Activity Questionnaire. Inflammatory biomarkers were measured by multiplex enzyme-linked immunosorbent assay. Compared with highly physically active participants based on total metabolic equivalent of task, the most sedentary group had significantly higher odds ratio and [95% confidence interval] for ≥75th percentile of TNF-α (1.64 [1.10-2.44]), TNF-β (1.50 [1.09-2.07]), IL-1β (2.14 [1.49-3.09]), hsIL-1β (1.72 [1.15-2.58]), IL-6 (1.84 [1.24-1.73]), hsIL-6 (2.05 [1.35-3.12]), and MCP-1 (1.91 [1.28-2.87]) levels. Results for IL-1α and MCP-3 were inconsistent, as the least active group had lower odds for above the median IL-1α (0.65 [0.49-0.95]) and MCP-3 (0.71 [0.54-0.93]) yet higher odds for ≥75th percentile IL-1α (2.36 [1.63-3.42]) and MCP-3 (2.44 [1.63-3.64]) levels. Based on duration of moderate-to-vigorous physical activity, sedentary participants had significantly higher odds for above median (1.40 [1.13-1.73]) and ≥75th percentile (1.33 [1.00-1.77]) IL-1β compared with those fulfilling the guideline recommendation. Subgroup analyses showed minimal sex differences. Routine inflammatory assessment may help to achieve primordial prevention of cardiovascular and metabolic diseases. Novelty: Healthy, middle-aged adults with physically active lifestyle were generally at lower odds for elevated inflammatory status. The associations persisted regardless of sex, age, comorbidities, adiposity, and diet. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Canadian Science Publishing | - |
dc.relation.isPartOf | APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers / blood* | - |
dc.subject.MESH | Exercise / physiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Healthy Lifestyle / physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Independent Living* | - |
dc.subject.MESH | Inflammation / blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Sedentary Behavior | - |
dc.title | Association between physical activity and inflammatory markers in community-dwelling, middle-aged adults | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | So Mi Jemma Cho | - |
dc.contributor.googleauthor | Hokyou Lee | - |
dc.contributor.googleauthor | Jee-Seon Shim | - |
dc.contributor.googleauthor | Justin Y Jeon | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.identifier.doi | 10.1139/apnm-2020-1069 | - |
dc.contributor.localId | A01142 | - |
dc.relation.journalcode | J04277 | - |
dc.identifier.eissn | 1715-5320 | - |
dc.identifier.pmid | 33566730 | - |
dc.identifier.url | https://cdnsciencepub.com/doi/10.1139/apnm-2020-1069 | - |
dc.subject.keyword | activité physique | - |
dc.subject.keyword | cytokines | - |
dc.subject.keyword | epidemiology | - |
dc.subject.keyword | exercice | - |
dc.subject.keyword | exercise | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | metabolic syndrome | - |
dc.subject.keyword | physical activity | - |
dc.subject.keyword | syndrome métabolique | - |
dc.subject.keyword | épidémiologie | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.citation.volume | 46 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 828 | - |
dc.citation.endPage | 836 | - |
dc.identifier.bibliographicCitation | APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, Vol.46(7) : 828-836, 2021-07 | - |
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