Cited 4 times in
Differential Long-Term Effects of First- and Second-Generation DES in Patients With Bifurcation Lesions Undergoing PCI
DC Field | Value | Language |
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dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2022-09-14T01:26:23Z | - |
dc.date.available | 2022-09-14T01:26:23Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2772-3747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190447 | - |
dc.description.abstract | Background There is a paucity of data regarding the long-term clinical outcomes of first- versus second-generation drug-eluting stent (DES), especially when used to treat complex lesions such as bifurcation lesions. Objectives The current study compares the efficacy and safety of first- versus second-generation DES at the 5-year follow-up in patients who underwent bifurcation percutaneous coronary intervention (PCI). Methods A total of 5,498 patients with a bifurcation lesion who underwent PCI were pooled at a single patient level from COBIS (Coronary Bifurcation Stenting) registries II and III. Five-year target lesion failure (TLF) (the composite of cardiac death, myocardial infarction [MI], and target lesion revascularization [TLR]) and cardiac death or MI were compared between the use of first-generation DES (n = 2,436) and second-generation DES (n = 3,062) during PCI. Propensity score matching was performed to reduce selection bias. Results After a 1:1 propensity score matching procedure was conducted, the cohort consisted of 1,702 matched pairs. Patients treated with second-generation DES had a significantly lower risk of TLF at 5 years than those treated with first-generation DES in both overall and propensity-matched populations (matched hazard ratio [HRmatched]: 0.576; 95% confidence interval [CI]: 0.456 to 0.727; p <0.001). There were no significant differences in risk of a composite of cardiac death or MI between the 2 groups (HRmatched: 0.782; 95% CI: 0.539 to 1.133, P = 0.193). However, among patients who required a 2-stent technique, use of the second-generation DES reduced cardiac death or MI (HRmatched:0.422; 95% CI: 0.209 to 0.851, P = 0.016). On the other hand, among patients who required a one-stent technique, the risk of a composite of cardiac death or MI was similar between the 2 groups (HRmatched: 1.046; 95% CI: 0.664 to 1.650, P = 0.845). There was a significant interaction between stent generation and treatment strategy for cardiac death or MI (interaction P = 0.029). Conclusions In patients treated with PCI for a bifurcation lesion, the use of second-generation DES was associated with a significantly reduced risk of 5-year TLF than the use of first-generation DES. (Korean Coronary Bifurcation Stenting Registry II [NCT01642992]; COBIS II) (Korean Coronary Bifurcation Stenting Registry III [NCT03068494] COBIS III) | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Ltd. | - |
dc.relation.isPartOf | JACC: Asia | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Differential Long-Term Effects of First- and Second-Generation DES in Patients With Bifurcation Lesions Undergoing PCI | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ki Hong Choi | - |
dc.contributor.googleauthor | Young Bin Song | - |
dc.contributor.googleauthor | Joo Myung Lee | - |
dc.contributor.googleauthor | Taek Kyu Park | - |
dc.contributor.googleauthor | Jeong Hoon Yang | - |
dc.contributor.googleauthor | Joo-Yong Hahn | - |
dc.contributor.googleauthor | Jin-Ho Choi | - |
dc.contributor.googleauthor | Seung-Hyuk Choi | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Woo Jung Chun | - |
dc.contributor.googleauthor | Seung-Ho Hur | - |
dc.contributor.googleauthor | Seung Hwan Han | - |
dc.contributor.googleauthor | Seung-Woon Rha | - |
dc.contributor.googleauthor | In-Ho Chae | - |
dc.contributor.googleauthor | Jin-Ok Jeong | - |
dc.contributor.googleauthor | Jung Ho Heo | - |
dc.contributor.googleauthor | Junghan Yoon | - |
dc.contributor.googleauthor | Do-Sun Lim | - |
dc.contributor.googleauthor | Jong-Seon Park | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Joon-Hyung Doh | - |
dc.contributor.googleauthor | Kwang Soo Cha | - |
dc.contributor.googleauthor | Doo-Il Kim | - |
dc.contributor.googleauthor | Sang Yeub Lee | - |
dc.contributor.googleauthor | Kiyuk Chang | - |
dc.contributor.googleauthor | Byung-Hee Hwang | - |
dc.contributor.googleauthor | So-Yeon Choi | - |
dc.contributor.googleauthor | Myung Ho Jeong | - |
dc.contributor.googleauthor | Soon-Jun Hong | - |
dc.contributor.googleauthor | Chang-Wook Nam | - |
dc.contributor.googleauthor | Bon-Kwon Koo | - |
dc.contributor.googleauthor | Hyeon-Cheol Gwon | - |
dc.identifier.doi | 10.1016/j.jacasi.2021.04.006 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A01281 | - |
dc.relation.journalcode | J04197 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2772374721000132 | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | 홍명기 | - |
dc.citation.volume | 1 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 68 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | JACC: Asia, Vol.1(1) : 68-79, 2021-06 | - |
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